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Hu Jin. Department of Dermatology, Affiliated Hospital of Children, Capital Institute of Pediatrics, Beijing 100020, China Corresponding author: Hu Jin, Email: hujin1970@sohu.com ��Abstract�� Objective To study the clinical and pathological features of lipodystrophia centrifugalis abdominalis ��LCA��. Methods The clinical and histopathological findings from 18 patients with LCA were analyzed retrospectively. Results Of the 18 patients, 12 were girls and 6 were boys, with the mean age at onset being 6.8 years ��range, 3��19 years��. The most common lesions were soft and atrophic patches with visible veins below them. Erythema was observed around the atrophic patches in one patient. The lesions were mainly located in the lower abdomen ��12 patients��, followed by the inguinal region ��11 patients��, vulva ��8 patients��, chest ��2 patients��, neck ��2 patients��, and axillary fossa ��1 patient��. Histopathologic findings in these lesions were consistent with LCA. A variety of treatments were given, including systemic therapies such as vitamin E and total glucosides of paeony capsulesm, as well as topical therapies such as mucopolysaccharide polysulfate cream, tacrolimus 0.03% ointment, pimecrolimus cream, and so on, whereas no apparent improvement was observed. Conclusion The diagnosis of LCA is mainly based on clinical and pathological findings.