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Wang Cui*, Xu Aie. *Hangzhou Clinical College Affiliated to Anhui Medical University, Hongzhou 310009, China Corresponding author: Xu Aie, Email: xuaiehz@msn.com ��Abstract�� Vitiligo is a common skin disorder due to the loss of cutaneous melanocytes. The exact mechanism underlying melanocyte loss remains unclear, and a large number of observations have pointed to an important role of cellular immunity in vitiligo pathogenesis. Under the action of some specific cytokines�� CD4+ T cells can differentiate into T helper 17 ��Th17�� cells that are involved in the pathogenesis of many diseases�� The initiation of vitiligo is associated with an increase in the number and activity of Th17 cells and dendritic cells�� Besides interleukin 17 ��IL-17��, Th17 cells secrete IL-6�� IL-21�� IL-22, tumor necrosis factor-α ��TNF-α��, etc, which may take part in the pathogenesis of vitiligo by inducing decreased generation, shrinkage and disappearance of melanocytes followed by diminished production of melanin��