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Jia Weixue, Li Chengrang. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding author��Li Chengrang, Email: nylcr72@163.com ��Abstract�� Vitiligo is a kind of common skin disorder characterized by hypopigmentation. The pathogenesis of vitiligo is complex and not yet fully understood. Although many treatment options are available, therapeutic efficacy is unsatisfied. Studies have shown that systemic corticosteroids can arrest the progression of vitiligo and lead to repigmentation through its anti-inflammatory and immunosuppressive effects. The modalities of corticosteroid administration include low-dose daily use, intermittent therapy, pulse therapy, with or without combined topical therapy, phototherapy or surgical therapy. The selection of modalities should depend on the type and stage of vitiligo to achieve best therapeutic efficacy and minimize side effects.