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Yang Jianqiang, Zheng Min. Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China Corresponding author: Zheng Min, Email: minz@zju.edu.cn ��Abstract�� Psoriasis is a chronic inflammatory dermatosis characterized by the overproliferation and impaired differentiation of epidermal keratinocytes. Abnormality exists throughout the full-thickness skin in psoriasis. Multiple types of cells and cytokines play critical roles in the pathogenesis of psoriasis. As the main constructive cell in the dermis, fibroblasts play a crucial role during cutaneous wound healing. Furthermore, fibroblasts provide favorable micro-environment for the differentiation, proliferation and maturation of keratinocytes, and modulate the function of other cells by expressing some intercellular adhesion molecules, receptors or surface markers and secreting multiple cytokines. Therefore, fibroblasts may play an important role in the pathogenesis of psoriasis.