1. �½�ҽ�ƴ�ѧ�о���Ժ
2. �½�ά�������������ҽԺƤ���Բ���

��ժҪ�� ��������Դ�ڱ�Ƥ����ϸ��������������ߵĶ���������Ŀǰ�����򽫺�������Ϊ�������ͣ�֫���͡��Ĥ�͡������չ������ͺͷ������չ������͡�����ѧ�о��л������غ��Ŵ��׸����Ǻ�������Ҫ�²����ء�kit�����Ƕ�λ������Ⱦɫ��4q11-12��ԭ�������о����֣��������޺�������Ҫ���²�����kit������֫���ͺ��Ĥ�ͺ�������ͻ���ʽϸߣ��Ժ���������������Ԥ���жϾ�����Ҫ���塣���kit����ķ��Ӱ���������Ŀǰ�о����ȵ㡣

Shi Xiaohui*, Kang Xiaojing. *Graduate School of Xinjiang Medical University, Urumqi 830000, China Corresponding author: Kang Xiaojing, Email: drkangxj666@163.com ��Abstract�� Melanoma, a malignant tumor originated from epidermal melanocytes, presents the highest mortality rate of all types of skin cancers. At present, melanoma is classified into four subtypes: acral melanoma, mucosal melanoma, skin melanoma with chronic sun-induced damage, and skin melanoma without chronic sun-induced damage. Environmental factors and genetic susceptibility are considered to be the key pathogenic mechanisms in melanoma. Kit gene, an oncogene located on chromosome 4q11-12, is considered to be an important pathogenic factor for melanoma in Asian. The mutations of kit gene, which are of great value for the growth and prognosis prediction of melanoma, are more common in acral and mucosal melanoma than in other types of melanoma. The kit gene-targeted therapy has become a hot spot in recent studies.

������Ȼ��ѧ������Ŀ;�½�ά�����������Ȼ������Ŀ