1. ����ҽ�ƴ�ѧƤ�����о���������ҽ�ƴ�ѧ��һ����ҽԺƤ���Բ���
2. ����ҽ�ƴ�ѧ��һ����ҽԺƤ����

��м����һ��������֢��Ƥ���������䲡���漰�Ŵ����������������ߵȶ෽�����ء�������������GWAS�о��Ľ�չ���ڶ���м���׸�λ��½�������֣�ERAP1�����������֮һ����������������Ⱥ���о���������ERAP1��������SNPs����м����أ�����HLA-C֮����ܴ��ڽ������á�ERAP1����HLA-I����ӷ����ļӹ����������ϸ��Ĥ��������ķ����йء�ERAP1���������ߵ��ڣ�������CD8+Tϸ���Ļ�йأ�����������ϸ����ϸ�����ӹ�ͬ���ã��շ���ά����м����Ƥ��

PAN Qian, YAO Wei-yi, ZHANG An-ping. Institute of Dermatology; Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei 230032, China Corresponding author: ZHANG An-ping, Email: zapamu@163.com ��Abstract�� Psoriasis is a chronic inflammatory skin disease. The pathogenesis of psoriasis remains unclear, and is considered to be associated with genetics, environment and autoimmunity. In recent years, with the progress in genome-wide association studies, numerous susceptibility loci have been successively identified for psoriasis, including the endoplasmic reticulum aminopeptidase-1��ERAP1�� gene. A lot of single nucleotide polymorphisms ��SNPs�� inside the ERAP1 gene have been repeatedly confirmed to be associated powerfully with psoriasis in nearly all ethnic/racial populations, and there might be some interactions between ERAP1 and HLA-C. ERAP1 is also involved in the trimming of HLA class I molecules to an optimal length and in the cleavage of several cytokine cell surface receptors. Moreover, ERAP1 takes part in immune regulation, in particular the activation of CD8+ T cells, and plays a certain role in the induction and maintenance of psoriatic lesions via cooperating with other inflammatory cells and cytokines. ��Key words�� Psoriasis; ERAP1; HLA-C antigens

LCE��������м��������������о�