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Institute of Dermatology of Guangxi Zhuang Autonomous Region, Nanning 530003, China

It has been demonstrated that the accumulation of epidermal hydrogen peroxide(H₂O₂) increases oxidative stress in patients with vitiligo.H₂O₂ can cause damage of melanocytes and dishmbance in melanogenesis via direct cytotoxic effect on epidermal cells,interference with tetrahydrobiopterin metabolism and inhibition of cellular enzyme activity in epidermal cells.The removal of epidermal H₂O₂ may lead to repigmentation of,disappearance of foams in epidermal cells,and recovery of epidermal cell shape in vitiligo lesions,which demonstrates that the pathogenesis of vitiligo is closely related to epidermal H₂O₂.