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Department of Dermatology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China

Cutaneous Rosai-Dorfinan disease is a rare disease,and little is known about its etiology and pathogenesis. Its skin lesions vary, and it is histopathologically characterized by proliferation of histiocytes and emperipolesis of engulfed lymphocytes in dennis. These histiocytes are stained positive for 5-100 protein and CD68(KP-1),but negative for CDla(OKT6).It is a self-limited disease and does not need specific treatment. This article reviews the etiology, pathogenesis, clinical manifestations, histopathology characteristics, diagnosis, differential diagnosis, treatment and prognosis of the disease.