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| PubMed | |
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Article by YE Yuan-yuan |
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Article by GAO Jin |
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, �人, 430022;
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Genes related to lichen sclerosus et atrophicus and squamous cell carcinoma of vulva
Department of Dermatology, Wuhan No.1 Hospital, Wuhan 430022, China
Department of Dermatology, Wuhan No.1 Hospital, Wuhan 430022, China
Lichen sclerosus et atrophicus(LSA) is a kind of chronic skin mucous disease, and often develop into vulvar squamous cell carcinoma (VSCC)Recently, it has been shown that many oncogenes and anti-oncogenes are closely related to the transformation of LSA to VSCC. This article reviews LSA-and VSCC-related oncogenes and anti-oncogenes, such as p53, bcl-2/bax, p16, EGFR, HPV and hTERT, and analyzes the genetic reasons in transformation process from LSA to VSCC.