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Tianjin Medical College General Hospital, Tianjin 300052, China

Atopic dermatitis is a chronic,inflammatory skin disease caused by a genetic anaphylactic predisposition and influenced by environmental triggering factors.Recent years,researchers have done a lot of research on gene locus and gene therapy for atopic dermatitis.It is evident that atopic dermatitis is associated with some gene locus,such as SPINK5,PHF11,and epidermal ditfcrcntiation genes.Vene therapy was also tried to treat patients with the disease,including topical delivery of an antisense oligonucleotide for IL-10, UVAI phototherapy,topical administration of NF-��B containing oligodeoxynucleotide cream,and so on.