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Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

In recent years, several changes in structural components of desmosomes have been reported. Desmosomes are cell-cell complexes found primarily in epithelial tissues. They constitute the major intercellular adhesion mechanism, allowing cells to withstand trauma. The structural components of desmosome include plakophilin 1, plakophilin 2, desmoplakin, desmoglein 1, desmoglein 4, plakoglobin and corneodesmosin. Any change of above components could lead to hair abnormalities. Further analysis of these and other desmosome components is likely to resolve more hair disease mysteries and provides several further intriguing new discoveries in years to come.