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Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjiing 210029, China

Imiquimod, an imidazoquinoline amine, is an immune response modifier. Since its appearance on the market, with its antiviral and antitumor properties, the drug has been used in the treatment of a variety of dermatologic conditions, including skin tumors, viral infections, and hyperplastic diseases. In this review article, the basic mechanism of action of imiquimod, and key points of medication methods, adverse reactions, and use in combination therapy for several skin tumors are discussed. It would be of benefit for us to be aware of the current and potential uses of imiquimod.