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Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China

Tacrolimus and pimecrolimus are new calcineurin inhibitors which are topically used in the treatment of atopic dermatitis. There are some debates on the safety of the two drugs recently. In reviewing available data topical tacrolimus and pimecrolimus are safc with no skin atrophy and low percutaneous absorption. There is no evidence suggesting that the immune system is inhibited obviously and the risk of cutaneous or systemic infection and cancer is increased with the application of the two drugs.