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��Abstract�� Objective To evaluate the clinical efficacy of intense pulsed light combined with tacrolimus 0.03% ointment in patients with facial seborrheic dermatitis. Methods Forty-five patients with facial seborrheic dermatitis were enrolled in this study, and classified into two groups: the treatment group ��n =24�� treated with intense pulsed light once every 3 weeks for 3 times plus topical tacrolimus 0.03% ointment twice daily, and the control group ��n = 21�� treated with topical tacrolimus 0.03% ointment twice daily alone for 4 weeks. Clinical outcomes were evaluated half a month after the end of the treatment. Results Pruritus, erythema and scaling were obviously improved in both groups. The clinical response rate was 87.50% in the treatment group, significantly higher than that in the control group ��57.14%��. Topical tacrolimus ointment induced a transient irritant reaction in 7 patients. Transepidermal water loss ��TEWL��, skin erythema index and skin sebum content significantly decreased, while skin elasticity significantly increased in the treatment group when compared with those before treatment ��all P < 0.05��. Conclusion Intense pulsed light combined with tacrolimus 0.03% ointment is a safe and effective treatment option for patients with facial seborrheic dermatitis. ��Key words�� Dermatitis, seborrheic; Tacrolimus; IPL