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��Abstract�� As a major event in type��allergic reaction, degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors ��FcεRIs�� on mast cell membrane, and is followed by the release of a battery of inflammatory mediators, such as histamine, leukotrienes and arachidonic acid, and these inflammatory mediators in turn induce a series of allergic symptoms. Recently, Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells. The crosslinking of Allergin-1 to FcεRIs on mast cells may inhibit the signal transduction from FcεRIs to intracellular immunoreceptor tyrosine-based inhibitory motif ��ITIM��, generate ITIM inhibitory signals, which then participate in the regulation of mast cell degranulation, and finally block the initiation of allergic inflammation. ��Key words�� Allergens; Allergin-1; Mast cells

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