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YU Rui-xing, CHEN Shao-chun, YIN Yue-ping. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding author: YIN Yue-ping, Email: yinyp@ncstdlc.org ��Abstract�� As the cause of gonorrhea, Neissria gonorrhea ��NG�� can result in urethritis and cervicitis. NG infection is usually treated by antibiotics in clinical practice. With the wide use of antibiotics in the treatment of NG infection, there have been evidences for increasing resistance to penicillin, tetracycline and quinolones in NG. At present, cephalosporins, mainly including ceftriaxone and cefixime, are the first-line treatment of NG infection. Unfortunately, reducing sensitivity to cephalosporins has been reported in NG worldwide. In 2010, NG strains with high level of resistance to multiple antibiotics, also called NG superbug, were found in Japan, France and Spain. Hence, there is an urgent need to develop new strategies to control NG infection. The World Health Organization has proposed that individualized strategies should be developed for the treatment of NG infection according to surveillance results in different countries. These strategies include increasing the dose of ceftriaxone, combining multiple drugs, etc. ��Key words�� Neisseria gonorrhoeae; Drug tolerance�� Therapy

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