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WU Wei, LUO Dan. Department of Dermatology and Venereology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Corresponding author: LUO Dan, Email: daniluo2005@yahoo.com.cn ��Abstract�� Ultraviolet ��UV�� irradiation can cause immune suppression, DNA damage and skin tumors. Toll-like receptors ��TLRs��, as important pattern recognition receptors, play essential roles in both innate and adaptive immune responses, and are expressed on a variety of cell types in skin, including keratinocytes, Langerhans cells, dendritic cells, mast cells, fibroblasts and melanocytes. TLR activation can upregulate the expression of cytokines, chemokines, and costimulatory and adhesion molecules involved in innate and adaptive immune responses. Mounting evidences have suggested that TLRs are associated with cellular responses to UV exposure. In addition, there has been a growing interest in the targeting of TLRs for the prevention and treatment of skin cancer. ��Key words�� Toll like receptors; Immunity; Ultraviolet rays; Skin neoplasms