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QU Yan-gang*, TANG Ai-ping, WANG Hong-li, LI Hong, CHEN Su. *Department of Pathology, Central Hospital of Enshi Autonomous Prefecture, Enshi 445000, Hubei, China Corresponding author: QU Yan-gang, Email: qygtap2@yahoo.com.cn ��Abstract�� A 56-year old man developed a raised nodule on the left forearm half a year before 2006, which gradually enlarged. Skin examination revealed a mass measuring 3 cm in diameter at the extensor aspect of left forearm, which was fixed, slightly deep-colored, adherent to the skin with an unclear margin. There was a postoperative scar measuring 2.5 cm in length. Histopathological examination revealed small- to medium-sized round or oval lymphocytes with fine chromatin, unclear nucleoli, a small amount of lightly stained cytoplasm. Immunophenotype analysis showed that the tumor cells were positive for terminal deoxynucleotidyl transferase ��TDT��, leucocyte common antigen ��LCA��, PAX5��paired box 5��, CD79a, CD10, Ki-67 ��50%��, but negative for CD20, CD3, CD30, epithelial membrane antigen ��EMA��, CD5, CD23 and CD56. He was pathologically diagnosed with cutaneous B-cell lymphoblastic lymphoma, and given combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone. Unfortunately, the condition was poorly controlled, and the patient died 4 years and 9 months later. ��Key words�� Lymphoma, lymphoblastic�� Case reports ��publication type��