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Hedgehog�ź�ͨ·�����ϸ����
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����ϸ�����������Ƥ����������֮һ����������о�����Hedgehog�ź�ͨ·��Hedge-hog����Patched����Smoothened����Gli����ȵ�ͻ��ʹHedgehog�ź�ͨ·Ŀ�Ļ���GLI2��WNT��HIP�ȵij��������ڻ���ϸ�����ķ�����չ����ؼ�������,����������ͨ·�Ļ��Զ����ƻ���ϸ��������Ҫ��ָ�����塣
[2] Hammerschmidt M, Brook A, McMahon AP. The world according to hedgehog. Trends Genet, 1997, 13:14-21.
[3] Cohen MM Jr. The hedgehog signaling network. Am J Med Genet A,2003,123:5-28.
[4] Ho KS, Scott MP. Sonic hedgehog in the nervous system:functions,modifications and mechanisms. Curr Opin Neurobiol, 2002, 12:57-63.
[5] Chen Y, Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell, 1996, 87:553-563.
[6] Alcedo J, Ayzenzon M, Von Ohlen T, et al. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell, 1996, 86:221-232.
[7] van den Heuvel M, Ingham PW. smoothened encodes a receptorlike serpentine protein required for hedgehog signalling. Nature,1996, 382:547-551.
[8] Couve-Privat S, Le Bret M, Traiffort E, et al. Functional analysis of novel sonic hedgehog gene mutations identified in basal cell carcinomas from xeroderma pigmentosum patients. Cancer Res,2004, 64:3559-3565.
[9] Oro AE, Higgins KM, Hu Z, et al. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science. 1997, 276:817-821.
[10] Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell, 1996, 85:841-851.
[11] Wicking C, Shanley S, Smyth I, et al. Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. Am J Hum Genet, 1997, 60:21-26.
[12] Zaphiropoulos PG, Unden AB, Rahnama F, et al. PTCH2, a novel human patched gene, undergoing alternative splicing and upregulated in basal cell carcinomas. Cancer Res, 1999, 59:787-792.
[13] Lam CW, Xie J, To KF, et al. A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene, 1999, 18:833-836.
[14] Nilsson M, Unden AB, Krause D, et al. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.Proc Natl Acad Sci U S A, 2000, 97:3438-3843.
[15] Ikram MS, Neill GW, Regl G, et al. GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. J Invest Dermatol, 2004, 122:1503-1509.
[16] Bale AE, Yu KP. The hedgehog pathway and basal cell carcinomas.Hum Mol Genet, 2001, 10:757-762.
[17] Bonifas JM, Pennypacker S, Chuang PT,et al. Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol, 2001, 116:739-742.
[18] Vogt A, Chuang PT, Hebert J, et al. Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. J Exp Med, 2004, 199:753-761.
[19] Athar M, Li C, Tang X,et al. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res, 2004, 64:7545-7552.
[20] Williams JA, Guicherit OM, Zaharian BI,et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway:effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A,2003, 100:4616-4621.
[21] Li C, Chi S, He N,et al. IFNalpha induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling. Oncogene, 2004, 23:1608-1617.