|
��չ����
|
|
| ������Ϣ | |
 |
Supporting info |
|
PDFȫ�� |
|
[HTMLȫ��] |
|
����� |
| �����뷴�� | |
|
�������ù����� |
|
���� |
|
Email Alert |
|
���·��� |
|
���������Ϣ |
| ���Ĺؼ���������� | |
|
��Ŷ� |
|
ϸ��˥�� |
|
Ƥ������ |
| ��������������� | |
|
Ǯ�� |
|
������ |
|
���� |
|
��ǧ�� |
| PubMed | |
|
Article by QIAN Ge |
|
Article by JIANG Fa-xing |
|
Article by TAO Xiao-hua |
|
Article by WANG Qian-qiu |
��Ŷ���Ƥ������
Ǯ��1, ������3, ��С��2, ��ǧ��2
1. �й�ҽѧ��ѧԺƤ�����о���, �Ͼ�210042;
2. ����ʡ����ҽԺ;
3. ����ʡ����ҽԺ
������ܶ༲���ķ����������,��Ƥ����Ӱ��Ҳ���ݺ��ӡ���Ŷ������������е���Ҫ�ɷ�֮һ,������ѧ����ʮ�ָ��ӡ�Ƥ����֯�еĽ����γ�ϸ��������άϸ����Ѫ���ж�����Ŷ�����ı���Ŷ����Դٽ�Ƥ��Ѫ������,��ɾֲ�Ƥ��ȱѪ,�ƻ������γ�ϸ���ڻ������ȶ�,����Ƥ���ϻ�,�ӻ�Ƥ����������,����һЩƤ��������Ŀǰ,��Ŷ���ܶ�Ƥ�����Ĺ�ϵ������ʮ�����,��Ƥ����֯��Ӱ�����û��кܴ�����顣���,��Ŷ���Ƥ�������û���Ҫ����һ�����о���
Nicotine and skin health
Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, 210042, China
Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, 210042, China
Smoking is closely related to the development of many diseases, and its influence on skin should not be ignored. Nicotine is the primary component of cigarette smog, with complex biological functions. Nicotinic receptors are expressed on keratinocytes, fibroblasts and blood vessels in skin tissue. Nicotine can induce the vasoconstriction to cause localized ischemia of skin, disturb the stabilization of keratinocyte internal environment, cause skin aging, slow the wound healing of skin, and lead to some cutaneous diseases. Now, the relation of nicotine with skin are unclear, and the effect of nicotine on skin tissue is controversial. So, further studies are needed for the effects of nicotine on skin.
[2] Kelley AE.Nicotinic receptors:addiction's smoking gun?Nat Med,2002,8(5):447-449.
[3] Sgard F,Charpantier E,Bertrand S,et al.A novel human nicotinic receptor subunit,alpha10,that confers functionality to the alpha9-subunit.Mol Pharmacol,2002,61(1):150-159.
[4] Grando SA,Horton RM,Pereira EF,et al.A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes.J Invest Dermatol,1995,105(6):774-781.
[5] Zia S,Ndoye A,Lee TX,et al.Receptor-mediated inhibition of keratinocyte migration by nicotine involves modulations of calcium jnflux and intracellular concentration.J Pharmacol Exp Ther,2000m,293(3):973-981.
[6] Nguyen VT,Chernyavsky AI,Arredondo J,et al.Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes.Exp Cell Res,2004,294(2):534-549.
[7] Nguyen VT,Arredondo J,Chernyavsky AI,et al.Keratinocyte acetyrlcholine receptors regulate cell adhesion.Life Sci,2003,72(18-19):2081-2085.
[8] Arredondo J,Nguyen VT,Chernyavsky AI,et al.Central role of alpha 7 nicotinic receptor in differentiation of the stratificatious squamous epithelium.J Cell Biol,2002:159(2):325-336.
[9] Grando SA.Receptor-mediated action of nicotine in human skin.Int J Dermatol,2001,40(11):691-693.
[10] Arredondo J,Nguyen VT,Chernyavsky AI,et al.Functional rote of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.Life Sci,2003,72(18-19):2063.
[11] Arredondo J,Hall LL,Ndoye A,et al.Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine.Lab Invest,2003,83(2):207-225.
[12] Leow YH,Maibach HI.Cigarette smoking,cutaneous vasculature,and tissue oxygen.Clin Dermatol,1998,16(5):579.
[13] Mavropoulos A,Aars H,Brodin P.Hyperaemic response to cigarette smoking in healthy gingiva.J Clin Periodontol,2003,30(3):214-221.
[14] Kirkpatrick CJ,Bittinger F,Nozadze K,et al.Expression and function of the non-neuronal cholinergic system in endothelial cells.Life Sci,2003,72(18-19):2111-2116.
[15] Miao FJ,Green PG,Benowitz N,et al.Central terminals of nociceptors are targets for nicotine suppression of inflammation.Neuroscience,2004,123(3):777-784.
[16] Wang H,Yu M,Ochani M,et al.Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation.Nature,2003,421(6921):384-388.
[17] Mills CM.Cigarette smoking,cutaneous immunity,and inflammatory response.Clin Dermatol,1998,16(5):589-594.
[18] Denda M,Fuziwara S,Inoue K.Influx of calcium and chloride ions into epidermal keratinocytes regulates exocytosis of epidermal lamellar bodies and skin permeability barrier homeostasis.J Invest Dermatol,2003,121(2):362-367.
[19] Hagforsen E,Edvinsson M,Nordlind K,et al.Expression of nicotinic receptors in the skin of patients with palmoplantar pustulosis.Br J Dermatol,2002,146(3):383-391.
[20] Grando SA.New approaches to the treatment of pemphigus.J Investig Dermatol Symp Proc,2004,9(1):84-91.
[21] Mehta JN,Martin AG.A case of pemphigus vulgaris improved by cigarette smoking.Arch Dermatoi,2000,136(1):15.
[22] Kanekura T,Uchino Y,Kanzaki T.A case of malignant atrophic papolosis Successfully treated with nicotine patches.Br J Dermatol,2003,149(3):660-662.
[23] Kanekura T,Usuki K,Kanzaki T.Skin disorders with prominent eosinophilic infiltration treated successfully with nicotlne.Report of two cases.Dermatology,2004,208(2):153-157.