|
��չ����
|
|
| ������Ϣ | |
 |
Supporting info |
|
PDFȫ�� |
|
[HTMLȫ��] |
|
����� |
| �����뷴�� | |
|
�������ù����� |
|
���� |
|
Email Alert |
|
���·��� |
|
���������Ϣ |
| ���Ĺؼ���������� | |
|
��ɫ�� |
|
���� |
|
������ |
| ��������������� | |
|
���� |
|
������ |
| PubMed | |
|
Article by ZHOU Hui |
|
Article by HAN Jian-de |
����
����, ������
��ɽ��ѧ������һҽԺƤ����, 510080
������ɫ��������Բ�λ���Բ�ξ�����ɫ�ؼ���Ϊ����,���������Ǻ�������ϸ���롣CD8+Ϊ����Tϸ�������ϸ���Ƿ��������еĹؼ����ڡ���������硢�������ڿ�ԭ�����߷�Ӧģʽ����������ء�����Ŀǰ��Ϊ,�����뻼�߽����������õ����Ʋ���,�������г�������ƽϢ��������,��˶��ڵ���Ƥ��,�����г�Ҳ���Ϊ���ʡ�
Halo nevus
Department of Dermatology, First Affiliated Hospital, Zhongshan University, Guangzhou 510080, China
Department of Dermatology, First Affiliated Hospital, Zhongshan University, Guangzhou 510080, China
Halo nevus(HN) is characterized by a pigmented nevus surrounding by round or oval local depigmentation. The central nevus is usually an acquired nevocyte nevus. It plays a key role in the pathogenesis of HN that cytotoxic CD8+ T cells eliminate central nevus. HN is closely correlated with vitiligo and melanoma in antigens and immune response pattern. Though clinical follow-up is commonly considered as the optimal treatment for HN presently, surgical resection could help to subside immunological activity in HN, so surgical resection may be more appropriate for single lesion of HN.
[2] Bayer-Garner IB,Ivan D,Schwartz MR,et al.The immunopathology of regression in benign lichenoid keratosis,keratoacanthoma and halo nevus.Clin Med Res,2004,2(2):89-97.
[3] de Vijlder HC,Westerhof W,Schreuder GM,et al.Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study.Pigment Cell Res,2004,17(3):270-274.
[4] Gupta S,Gupta S,Mahendra A,et al.Inverse halo nevus.Dermatol Surg,2006,32(6):871-872.
[5] Hapif TP.Nevi and Malignant Melanoma.In:Habjf TP,eds.Clinical Dermatology:a color guide to diagnosis and therapy.4th ed.Philadelphia:Mosby.2004:781.
[6] Halo nevus.In:James WD,Berger TG,Elston DM,eds.Andrews' diseases of the skin:clinical dermatology.10th ed.Saunders:Elsevier,2006:689-690.
[7] Bergman W,Willemze R,de Graaaff-Reitsma C,et al.Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi.J Invest Dermatol,1985,85(1):25-29.
[8] Moretti S,Spallanzani A,Pinzi C,et al.Fibrosis in regressing melanoma versus nonfibrosis in halo nevus upon melanocyte disappearance:could it be related to a different cytokine microenvironment?J Cutan Pathol,2007,34(4):301-308.
[9] Hu Z,Liu JB,Ma SS,et al.Profile of childhood vitiligo in China:an analysis of 541 patients.Pediatr Dermatol,2006,23(2):114-116.
[10] Dogra S,Parsad D,Handa S,et al.Late onset vitiligo:a studyof 182 patients.Int J Dermatol,2005,44(3):193-196.
[11] Schallreuter KU,Kothari S,Elwary S,et al.Molecular evidence that halo in Sutton's naevus is not vitiligo.Arch Dermatol Res,2003,295(6):223-228.
[12] Copeman PW,Lewis MG,Phillips TM,et al.Immunological associations of the halo naevus with cutaneous malignant melanoma.Br J Dermatol,1973,88(2):127-137.
[13] Arpaia N,Cassano N,Vena GA.Regressing cutaneous malignant melanoma and vitiligo-1ike depigmentation.Int J Dermatol,2006,45(8):952-956.
[14] Mitchell MS,Nordlund JJ,Lerner AB.Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo,halo nevi or melanoma.J Invest Dermatol,1980,5(2):144-147.
[15] Lai C,Lockhart S,Mallory SB.Typical halo nevi in childhood:is a biopsy necessary?J Pediatr,2001,138(2):283-284.
[16] Baranda L,Torres-Alvarez B,Moncada B,et al.Presence of activatexl lymphocytes in the peripheral blood of patients with halo nevi.J Am Acad Dermatol,1999,41(4):567-572.