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PubMed
Article by WANG Peng
Article by ZHOU Xiao-hong
Article by DENG Dan-qi

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Monocyte chemoattractant protein-1 and systemic lupus erythematosus

Department of Dermatology, First Affiliated Hospital of Baotou Medical College, Baotou 014010, Neimeng, China

Department of Dermatology, First Affiliated Hospital of Baotou Medical College, Baotou 014010, Neimeng, China

Abstract:

Monocyte chemoattractant protein-1 (MCP-1) can lead to the chemotaxis and activation of monocytes. There is a high level of MCP-1 in serum and urine of patients with systemic lupus erythematosus, which may be related to the polymorphism of MCP-1 promoter. It is revealed that the level of MCP-1 in the patients with systemic lupus erythematosus has certain correlation with the disease activity. The study has commenced about MCP-1 in systemic lupus erythematosus therapy.

Keywords: Monocyte chemoattractant protein-1   Lupus erythematosus, systemic   Lupus nephritis  
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[1] Tucci M,Barnes EV,Sobel ES,et al.Strong association of a functional polymorphism in the monocyte ehcmoattractant protein l promoter gene with lupus nephritis.Arthritis Rheum,2004,50(6):1842-1849.
[2] Kim HL,Lee DS,Yang SH,et al.The polymorphism of monocyte chemoattractant protein-l is associated with the renal disease of SLE.Am J Kidney Dis,2002,40(6):1146-1152.
[3] Hwang SY,Cho ML,Park B,et al.Allelic frequency of the MCP-1 promoter-25 18 polymorphism in the Korean population and in Korean patients with rheumatoid arthritis,systemic lupus erythematosus and adult-onset Still's disease.Eur J Immunogenet,2002,29l 5):413-416.
[4] Nakashima H,Akahoshi M,Shimizu S,et al.Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis.Lupus,2004,13(3):165-167.
[5] Aguilar F,Gonzalez-E seribano MF,Sanchez-Roman J,et al.MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythgmatosus.Tissue Antigens,2001,58(5):335-338.
[6] Ye DQ,Hu YS,Li XP,et al.The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese.Arch Dermatol Res,2005,296(8):366-371.
[7] Liao CH,Yao TC,Chung HT,et al.Polymorphisms in the promoter region of RANTES and the regulatory region of monocyte chemoattractant protein-1 among Chinese children with systemic lupus erythematosus.J Rheumatol,2004,31(10):2062-2067.
[8] Dai C,Liu Z,Zhou H,et al.Monocyte chemoattractant protein-1 expression in renal tissue is associated with monocyte reeruitment and tubulo-interstitial lesions in patients with lupus nephritis.Chin Med J (Engl),2001,114(8):864-868.
[9] Rovin BH,Lu L,Marsh CB.Lymphocytes induce monoeyte chemoattractant protein-1 production by renal cells after Fc gamma receptor cross-linking:role of IL-1beta.J Leukoc Biol,2001,69(3):435-439.
[10] Rovin BH,Song H,Birmingham DJ,et al.Urine chemokines as biomarkers of human systemic lupus erythematosus activity.J Am Soc Nephrol,2005,16(2):467-473.
[11] Chan RW,Lai FM,Li EK et al.Expression of chemokine and fibrosing factor messenger RNA in the urinary sediment of patients with lupus nephritis.Arthritis Rheum,2004,50(9):2882-2890.
[12] Shimizu S,Nakashima H,Masutani K,et al.Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/1pr mice.Rhcumatology (Oxford),2004,43 (9):1121-1128.
[13] Shimizu S,Nakashima H,Karube K,et al.Monocyte chemoattractant protein-1 activates a regional Th1 immunoresponse in nephritis of MRL/1pr mice.Clin Exp Rheumatol,2005,23 (2):239-242.
[14] Hasegawa H,Kohno M,Sasaki M,et al.Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/1pr mice.Arthritis Rheum,2003,48(9):2555-266.
[15] Nozaki Y,Yamagata T,Yoo BS,et al.The beneficial effects of treatment with all-trans-retinoic acid plus corticosteroid on autoimmune nephritis in NZB-WF mice.Clin Exp Immunol,2005,139(1):74-83.
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