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��Ƥ��Բ�ѧ��־ 2007, 33(5) 302-304 DOI: ISSN: 2096-5540 CN: 32-1880/R

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	PubMed
	Article by LI Yuan-yuan
	Article by YAN Chun-lin

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Ultraviolet and cell signal transduction

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China

Abstract:

Ultraviolet(UV) irradiation has been proved to be able to inhibit immunity, induce cutaneous tumors and light aging, the mechanism of which is uncertain yet. Recent studies have shown that UV could interfere with the signal transduction pathway by acting on nucleic DNA, cell membrane receptors and multiple elements in cell plasma, cause abnormal signal transduction in cells, and induce various injuries to cells. The insight into UV irradiation and cell signal transduction will contribute to the elucidation of light damage and search of effectual protective measures.

Keywords: Ultraviolet rays Signal transducing DNA damage

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DOI:

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[1] Maeda T,Espino RA,Chomey EG,et al.Loss of p21WAF1/Cip1 in Gadd45-deficient keratinocytes restores DNA repair capacity.Carcinogenesis,2005,26 (10):1804.
[2] Menendez D,Inga A,Resnick MA.The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.Mol Cell Biol,2006,26 (6):2297-2308.
[3] Lee JK,Kim JH,Nam KT,et al.Molecular events associated with apoptosis and proliferation induced by ultraviolet-B radiation in the skin of hairless mice.J Dermatol Sci,2003,32 (3):171-179.
[4] Hsieh JK,Yap D,O'Connor DJ,et al.Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.Mol Cell Biol,2002,22 (1):78.
[5] Schwarz A,Maeda A,Kernebeck K,et al.Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair.J Exp Med,2005,201 (2):173-179.
[6] El-Abaseri TB,Putta S,Hansen LA.Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor.Carcinogenesis,2006,27 (2):225-231.
[7] Wang Q,Turlington A,Heo S,et al.Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes.Int J Mol Med,2005,15(4):633-640.
[8] Belleudi F,Leone L,Aimati L,et al.Endocytic pathways and biological effects induced by UVB-dependent or ligand-dependent activation of the keratinocyte growth factor receptor.FASEB J,2006,20 (2):395-397.
[9] Quan T,He T,Kang S,et al.Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type �� receptor/Smad signaling.Am J Pathol,2004,165 (3):741-751.
[10] Kimura H,Minakami H,Shoji A.Ultraviolet B irradiation modulates susceptibility to tumour necrosis factor-alpha-induced apoptosis via induction of death receptors in murine fibroblasts.Cell Biol Int,2001,25 (12):1221-1228.
[11] Bang B,Rygaard J,Baadsgaard O,et al.Increased expression of Fas on human epidermal cells after in vivo exposure to single-dose ultraviolet (UV) B or long-wave UVA radiation.Br J Dermatol,2002,147(6):1199-1206.
[12] Kim AL,Labasi JM,Zhu Y,et al.Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice.J Invest Dermatol,2005,124 (6):1318-1325.
[13] Adachi M,Gazel A,Pintucci G,et al.Specificity in stress response:epidermal keratinocytes exhibit specialized UV-responsive signal transduction pathways.DNA Cell Biol,2003,22(10):665-677.
[14] Kobayashi H,Yoshida R,Kanada Y,et al.A soybean Kunitz trypsin inhibitor reduces tumor necrosis factor-alpha production in ultraviolet-exposed primary human keratinocytes.Exp Dermatol,2005,14 (10):765-774.
[15] Lan CC,Yu HS,Wu CS,et al.FK506 inhibits tumour necrosis factor-alpha secretion in human keratinocytes via regulation of nuclear factor-kappaB.Br J Dermatol,2005,153 (4):725-732.
[16] Bodero AJ,Ye R,Lees-Miller SP.UV-light induces p38 MAPK-dependent phosphorylation of Bc110.Biochem Biophys Res Commun,2003,301 (4):923-926.
[17] Liu J,Yang D,Minemoto Y,et al.NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.Mol Cell,2006,21 (4):467-480.
[18] Wang HQ,Quan T,He T,et al.Epidermal growth factor receptor-dependent,NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3,-8,and -9 in human keratinocytes.J Biol Chem,2003,278 (46):45737-45745.
[19] Hirota A,Kawachi Y,Itoh K,et al.Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts:protective role in UVA-induced apoptosis.J Invest Dermatol,2005,124 (4):825-832.
[20] Moon HI,Chung JH.The effect of 2',4',7-trihydroxyisoflavone on ultraviolet-induced matrix metalloproteinases-1 expression in human skin fibroblasts.FEBS Lett,2006,580 (3):769-774.
[21] Inomata S,Matsunaga Y,Amano S,et al.Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse.J Invest Dermatol,2003,120 (1):128-134.
[22] Vayalil PK,Mittal A,Hara Y,et al.Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin.J Invest Dermatol,2004,122(6):1480-1487.
[23] Chung JH,Seo JY,Lee MK,et al.Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo.J Invest Dermatol,2002,119(2):507-512.

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