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| PubMed | |
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Article by YANG Sheng-bo |
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Article by WEN Hai-quan |
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Article by ZHANG Gui-ying |
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���ϴ�ѧ���Ŷ�ҽԺƤ���� ��ɳ 410011
������������ҩ��ֲ��������Ҫҩ����ԵĴ����Ե���֮һ,���п����ߡ����ס���������ҩ�����á�����Ҫ���û����ǻ�����춬ø������˿��ԭ�����ø�ź�ͨ·�����ƺ�����-��B��ʽ�������á��p53ͬʱ����p21�յ����������͵�,�Ӷ��յ�ϸ���������������������ź�ת���ĵ�����ϸ�����ͬ�����ڲ��졣
Effects of triptolide on cell apoptosis-related signal transduction
Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China
Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China
Triptolide, a diterpene triepoxide, is the principal active component of Tripterygium wilfordii Hook. F. abstracts. It has been shown to possess anti-inflammatory, immunosuppressive and anti-neoplastic properties, which are mainly related to the induction of apoptosis via the activation of caspase enzymes, mitogen-activated protein kinase signaling pathway and p53, as well as the inhibition of trans-activation by nuclear factor-��B and growth arrest induced by p21, and so on. The effects of triptolide on the signal transduction vary with the types of cells.
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[14] Qiu D,Zhao G,Aoki Y,et al.Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation.J Biol Chem,1999,274 (19):13443-13450.
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[17] Kiviharju TM,Lecane PS,Sellers RG,et al.Antiproliferative and proapoptotic activities of triptolide (PG490),a natural product entering clinical trials,on primary cultures of human prostatic epithelial cells.Clin Cancer Res,2002,8 (8):2666-2674.
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