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��Ƥ��Բ�ѧ��־ 2006, 32(6) 374-376 DOI: ISSN: 2096-5540 CN: 32-1880/R

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	PubMed
	Article by BIAN Cai-yun
	Article by JIANG Xian

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Mechanisms of Ultraviolet Radiation-induced Apoptosis in Keratinocytes

West China Hospital, Sichuan University, Chengdu 610041, China

Abstract:

Ultraviolet (UV) radiation-induced apoptosis in keratinocytes have received considerable attention in recent years because of its close relationship with many pathological processes. UV radiation can cause generation of reactive oxygen species (ROS) and cytokines, DNA damage and changes of gene expression, and eventually induce apoptosis of keratinocytes. This process involves an array of signal transduction pathways, of which, those pathways mediated by p53, CD95, Bcl-2, caspase, mitogen-activated protein kinases play the most important roles.

Keywords: Ultraviolet rays Apoptosis Signal transduction Keratinocytes

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DOI:

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