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| PubMed | |
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Article by WU Qiao-Yun |
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Article by ZHENG Min |
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�㽭��ѧ�����ڶ�ҽԺƤ����, ����310009
��ͺ��һ�ַ�����ë�ҵķ����ԡ���֢�Լ���,�����ٴ���������֢����,����֯����ѧ�����ʾ,������ë�����ܰ�ϸ���������֢��������,�ٴ������ߵ��ڻ����Ƽ�������Ч����ͺ���������������й�,����֢ϸ���鵼�ġ����������Լ����������ද�����Է��ѷ�����,�䷢�������������ͺ����,���о������ද��(C3H/HeJС���DEBR��)��ͺ�������ͷ��������о���״��һ������
Pathogenesis of Alopecia Areata in C3H/HeJ Mice and DEBR Rats
Department of Dermatology and Venereology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
Department of Dermatology and Venereology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
Alopecia areata is a nonscarring, inflammatory disease of hair follicles. Histological changes are limited to anagen follicles that are surrounded by mononuclear cells and inflammatory mediators. This infiltration is composed primarily of cytotoxic (CD8+) and helper (CD4+) T cells. The infiltration is markedly reduced by intralesional injection of triamcinolone acetonide with subsequent hair re-growth in the affected site. Alopecia areata is suspected to be an autoimmune disease targeting hair follicles. The disease closely resembling human is found in a large production colony of C3H/HeJ mice and DEBR rats. The traits and pathogenesis of alopecia areata in C3H/HeJ mice and DEBR rats are discussed.
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