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| PubMed | |
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Article by LI Ya-ping |
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Article by LU Qian-jin |
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The Epigenetic Pathogenesis of Systemic Lupus Erythematosus
Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China
Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China
Epigenetic mechanisms, including DNA methylation,histone modification and chromatin remodeling,have been demonstrated to be involved in the development of SLE. The gene microenvironment composed of these factors could regulate gene transcription. DNA hypomethylation,likely to be cooperating with aberrant histone modification,may induce the activation of some T cell genes and development of autoimmunity in SLE. The abnormality of signal transduction and transcriptional regulatory protein is considered as two possible factors associated with epigenetic mechanisms.
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