|
��չ����
|
|
| ������Ϣ | |
 |
Supporting info |
|
PDFȫ�� |
|
[HTMLȫ��] |
|
����� |
| �����뷴�� | |
|
�������ù����� |
|
���� |
|
Email Alert |
|
���·��� |
|
���������Ϣ |
| ���Ĺؼ���������� | |
|
Toll������9 |
|
����Ǵ�,ϵͳ�� |
| ��������������� | |
|
��ʥ |
|
������ |
| PubMed | |
|
Article by FANG Sheng |
|
Article by ZENG Fan-qin |
Toll������9��ϵͳ�Ժ���Ǵ�
��ʥ, ������
��ɽ��ѧ�����ڶ�ҽԺƤ����, ����510120
ϵͳ�Ժ���Ǵ���һ�����������Լ�����Toll���������ʶ��ԭ��صķ���ģʽ�����߷�Ӧ������Toll������9ʶ��ϸ���Ͳ���DNA�е�CpG����,Ȼ��ͨ���ź�ת������Bϸ������ͻ״ϸ���Լ���������ϸ���������յ���������IJ��������������ʧ�⡣Խ��Խ����о�����,Toll������9������SLE�ķ�����չ�����з������á�
Toll-like Receptors and Systemic Lupus Erythematosus
Department of Dermatology, The Second Hospital, Zhongshan University, Guangzhou 510120, China
Department of Dermatology, The Second Hospital, Zhongshan University, Guangzhou 510120, China
Systemic lupus erythematosus is an autoimmune disease. The family of Toll-like receptors initiates immune response after recognition of pathogen-associated molecular patterns. Toll-like receptor 9 recognizes CpG motifs in microbial DNA. Then through the signal transfer,B lymphocytes and dendritic cells are activated, meanwhile different kinds of cytokines appear. At last, autoantibodies are produced and the immune network turns to be unbalanced. Evidences are accumulated that Toll-like receptor 9 (TLR 9) might play an important role in the initiation and progress of systemic lupus erythematosus. This review will summarize the latest advances in research on the role of TLR9 in systemic lupus erythematosus.
[2] Zarember KA,Godowski PJ.Tissue expression of human Toll-like receptors and differential regulation of Toll-ike receptor mRNAs in leukocytes in response to microbes,their products,and cytokines.J Immunol,2002,168:554-561.
[3] Latz E,Schoenemeyer A,Visintin A,et al.TLR9 signals after translocating from the ER to CpG DNA in the lysosome.Nat Immunol,2004,5:190-198.
[4] Akira S,Takeda K.Toll-ike receptor signalling.Nat Rev Immunol,2004,4:499-511.
[5] Vollmer J,Weeratna R,Payette P,et al.Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.Eur J Immunol,2004,34:251-262.
[6] Sato Y,Miyata M,Sato Y,et al.CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro.J Rheumatol,1999,26:294.
[7] Gilkeson GS,Pippen AM,Pisetsky DS.Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.J Clin Invest,1995,95:1398.
[8] Hemmi H,Takeuchi O,Kawai T,et al.A Toll-like receptor recognizes bacterial DNA.Nature,2000,408:740-745.
[9] Rifkin IR,Leadbetter EA,Busconi L,et al.Toll-like receptors,endogenous ligands,and systemic autoimmune disease.Immunol Rev,2005,204:27-42.
[10] Pisetsky D,Drayton D,Wu ZQ.Specificity of antibodies to bacterial DNA in the sera of healthy human subjects and patients with systemic lupus erythematosus.J Rheumatol,1999,26:1934-1938.
[11] Bemasconi NL,Onai N,Lanzavecchia A.A role for Toll-like receptors in acquired immunity:up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells.Blood,2003,101:4500-4504.
[12] Leadbetter EA,Rifkin IR,Hohlbaum AM,et al.Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-kike receptors.Nature,2002,416:603-607.
[13] Viglianti GA,Lau CM,Hanley TM,et al.Activation ofautoreactive B cells by CpG dsDNA.Immunity,2003,19:837-847.
[14] Christensen SR,Kashgarian M,Alexopoulou L,et al.Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.J Exp Med,2005,202:321-331.
[15] Blanco P,Palucka AK,Gill M,et al.Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.Science,2001,294:1540-1543.
[16] Boule MW,Broughton C,Mackay F,et al.Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.J Exp Med,2004,199:1631-1640.
[17] Means TK,Latz E,Hayashi F,et al.Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32and TLR9.J Clin Invest,2005,115:407-417.
[18] Sparwasser T,Vabulas RM,Villmow B,et al.Bacterial CpG-DNA activates dendritic cells in vivo:T helper cell-independent cytotoxic T cell responses to soluble proteins.Eur J Immunol,2000,30:3591-3597.
[19] Ito T,Wang YH,Liu YJ.Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9.Springer Semin Immunopathol,2005,26:221-229.
[20] Banchereau J,Pascual V,Palucka AK.Autoimmunity through cytokine-induced dendritic cell activation.Immunity,2004,20:539-550.
[21] Vissers JL,van Esch BC,Jeurink PV,et al.Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice.Respir Res,2004,5:21.
[22] He B,Qiao X,Cerutti A.CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10.J Immunol,2004,173:4479-4491.