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| PubMed | |
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Article by JIANG Fa-xing |
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Article by QI Mu-ge |
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Article by WANG Qian-qiu |
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Ⱦɫ��鵼������ù�ؼ����Ļ�����ҩ��ص���Ҫλ�����penA��ponA��penB��penC��mtr��tet����ù�ؽ�ϵ����г�����Ƕ״�ṹ��ͷ�߾��ص�����ԭ��֮һ���ŵͪ��ҩ������gyrA��parC��ͬ��λ��ͻ�䵼���ŵͪ��ҩ��������Դ��ù�ظ߶���ҩ������speλ�㵥��ͻ�����¡�������ҩ�����λ��ͻ����ء�
Molecular Mechanism of Chromosomally Mediated Resistance in Neisseria gonorrheae
Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
The chromosomally mediated penicillin and tetracycline resistance associated genes include penA, ponA, penB, penC, mtr and tet in Neisseria gonorrhoeae. The mosaic-like structure of penicillin-binding protein 2 gene (penA) is associated with reduced susceptibility to cephalosporin. Double gyrA mutations plus a parC mutation play an important role in the development of high-level fluoroquinolone resistance in N. gonorrhoeae. A single-step mutation in spe gene leads to the high-level spectinomycin resistance. The mutations at multiple loci are associated with multidrug-resistant phenotype.
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