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| PubMed | |
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Article by ZHENG Bo |
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Article by WANG Qian-qiu |
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�й�ҽѧ��ѧԺ���й�Э��ҽ�ƴ�ѧƤ�����о���, �Ͼ�210042
����������������������ֳ���������Ҫ��ԭ�塣���������ڵ������������ҩʱ�б����������о�֤��,���ռ�ø��DNA�ۺ�øȱ���ǵ��µ����������ҩ����Ҫ���ơ��ͽ�������HSV��ҩ������о�����̽�ֵ����������ҩ���������Ƽ�����ҩ���ơ�
The Prevalence of Drug-resistance HSV Strains and Its Mechanisms
Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
HSV is the major pathogen of herpes simplex and genital herpes. The increasing prevalence of GH has had a profound effect on the health of human beings in the world. The emergence of more and more drug-resistant HSV strains is associated with the widespread and frequent use of antiviral drugs in the treatment, suppressive therapy and prophylaxis of HSV infection, and with increasing of HIV infection. More and more drug-resistant HSV strains have been reported recently. The mutations in thymidine kinase and DNA polymerase genes are proved to be the main mechanism of drug-resistance. This review discusses the prevalence and mechanism of HSV drug-resistance.
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