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| PubMed | |
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Article by MA Yi-ping |
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Article by LU Xian-mei |
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T Cell Receptor Gene Rearrangement in Cutaneous T-cell Lymphomas
Shandong Provincial Institute of Dermatovenerology, Jinan 250022, China
Shandong Provincial Institute of Dermatovenerology, Jinan 250022, China
T cell receptor (TCR)gene rearrangement is an important event in T cell ontogeny that enables T cells to specifically recognise antigens, and any dysregulation in this process may result in diseases. Cuntaneous T-cell lymphoma(CTCL) is caused by malignant proliferation of individual lymphocyte, and its lesional tissue shows clonality of TCR gene rearrangement. Mycosis fungoides and Sezary syndrome are the most frequent clinical types of CTCL. The detection of TCR gene rearrangement has an important role in the study of the pathogenesis, classification, diagnosis and monitoring of prognosis of CTCL.
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