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| PubMed | |
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Article by HU Wei-wei |
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Article by LAO Li-min |
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�㽭��ѧҽѧԺ������ԺƤ����, ����310009
Ƥ��֬Ĥ����Tϸ���ܰ����ǽ�������ʶ���ټ���Ƥ��Tϸ���ܰ���,��Դ�ڦ���TCRTϸ����æ�TCRTϸ����ϸ������Tϸ����Ƥ��֬Ĥ����Tϸ���ܰ�����Ҫ����ΪƤ�¶�Խ�ڡ��߿��Ƥ����,���ֻ��߿ɰ�����Ѫϸ���ۺ���,�����չѸ�١������Ͽɼ�Ƥ��֬Ĥ�����ı�,���пɼ���ϸ��Χ�Ƶ���֬��ϸ���γ������Եġ��������ı䡱,�����黯����Ϊϸ������Tϸ����Դ,������TCR��æ�TCR��������,�Գ��滯�Ʒ�ӦǷ��,Ԥ��ϲ�,��Ԥ���������߱����йء�
Subcutaneous Panniculitis-like T Cell Lymphoma:Diagnosis and Management
Department of Dermatology, Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China
Department of Dermatology, Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China
Subcutaneous panniculitis-like T cell lymphoma(SPTCL) is a rare type of cutaneous T-cell lymphoma derived from cytotoxic T cells expressing either ���� or �æ�T cell receptors. Clinically, it usually presents with multiple subcutaneous nodules, plaques or masses. Some SPTCL patients may rapidly progress with the complication of hemophagocytic syndrome(HPS). Pathologically, SPTCL shows a subcutaneous panniculitis-like change with characteristic rimming of individual fat cell by tumor cells. Immunohistochemically,it is usually derived from cytotoxic T cells expressing clonal rearrangements of ���� or �æ� T-cell receptor(TCR) gene. SPTCL often poorly responses to routine chemotherapy, and has a poor prognosis, which is associated with the phenotype of SPTCL.
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