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Prevention and Treatment of Skin Photoaging With Topical Drugs | |||||||||||||||||||||||||||||||||||||||||||||||||
Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China | |||||||||||||||||||||||||||||||||||||||||||||||||
Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China | |||||||||||||||||||||||||||||||||||||||||||||||||
Abstract:
Photoaging refers to cutaneous damage caused by light, especially ultraviolet radiation exposure, in the process of skin aging. Photoaging can be complicated by many kinds of cutaneous diseases, and even results in cutaneous neoplasms. Thus it is necessary to prevent and treat skin photoaging. With further understanding of photoaging,many corresponding developments have been made in its prevention and treatment approaches. In this review a variety of topical drugs used in the prevention and treatment of skin photoaging, including sunscreen agents, retinoids and green tea, etc, are discussed about their mechanism of action, clinical use and curative effects. | |||||||||||||||||||||||||||||||||||||||||||||||||
Keywords: Skin aging External application drug Chemoprevention Therapy | |||||||||||||||||||||||||||||||||||||||||||||||||
�ո����� 2006-02-23 ������ ����淢������ | |||||||||||||||||||||||||||||||||||||||||||||||||
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[1] Young AR.Methods used to evaluate the immune protection factor of a sunscreen:advantages and disadvantages of different in vivo techniques.Cutis,2004,74 (5 Suppl):19-23. [2] Griffiths CE.The role of retinoids in the prevention and repair of aged and photoaged skin.Clin Exp Dermatol,2001,26:613-618. [3] Kang S,Leyden JJ,Lowe NJ,et al.Tazarotene cream for the treatment of facial photodamage:a multicenter,investigator-masked,randomized,vehicle-controlled,parallel comparison of 0.01%,0.025%,0.05%,and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks.Arch Dermatol,2001,137:1597-1604. [4] Lowe N,Gifford M,Tanghetti E,et al.Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin:a multicenter,double-blind,randomized,parallel-group study.J Cosmet Laser Ther,2004,6:79-85. [5] Stratigos AJ,Katsambas AD.The role of topical retinoids in the treatment of photoaging.Drugs,2005,65:1061-72. [6] Katiyar SK,Afaq F,Perez A,et al.Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress.Carcinogenesis,2001,22:287. [7] Katiyar SK.Skin photoprotection by green tea:antioxidant and immunomodulatory effects.Curr Drug Targets Immune Endocr Metabol Disord,2003,3:234-242. [8] Lin JY,Selim MA,Shea CR,et al.UV photoprotection by combination topical antioxidants vitamin C and vitamin E.J Am Acad Dermatol,2003,48:866-874. [9] Lin FH,Lin JY,Gupta RD,et al.Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin.J Invest Dermatol,2005,125:826-832. [10] Pinnell SR.Cutaneous photodamage,oxidative stress,and topical antioxidant protection.J Am Acad Dermatol,2003,48:1-22. [11] Bissett DL,Oblong JE,Berge CA.Niacinamide:A B vitamin that improves aging facial skin appearance.Dermatol Surg,2005,31:860. [12] Hoppe U,Bergemann J,Diembeck W,et al.Coenzyme Q10,a cutaneous antioxidant and energizer.Biofactors,1999,9:371-378. [13] Mitani H,Koshiishi I,Sumita T,et al.Prevention of the photodamage in the hairless mouse dorsal skin by kojic acid as an iron chelator.Eur J Pharmacol,2001,411:169-174. [14] Fulton JE,Porumb S.Chemical peels:their place within the range of resurfacing techniques.Am J Clin Dermatol,2004,5:179-187. [15] Kim TH,Choi EH,Kang YC,et al.The effects of topical alpha-hydroxyacids on the normal skin barrier of hairless mice.Br J Dermatol,2001,144:267-273. [16] Alberts DS,Dorr RT,Einspahr JG,et al.Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine.Cancer Epidemiol Biomarkers Prev,2000,9:1281-1286. [17] Budiyanto A,Ahmed NU,Wu A,et al.Protective effect of topically applied olive oil against photocarcinogenesis following UVB exposure of mice.Carcinogenesis,2000,21:2085-2090. [18] Wei H,Spencer J,Gelfand JM,et al.The Isoflavone Genistein:A New Agent in Dermatology? Cosmetic Dermatology,2001,14:13. [19] Tanaka S,Sato T,Akimoto N,et al.Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid,nobiletin,in human keratinocytes in vivo and in vitro.Biochem Pharmacol,2004,68:433-439. |
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1��ʯ��,����,����.������Ƥ�����ϻ�[J]. ����Ƥ���Բ�ѧ��־, 2006,32(3): 156- | |||||||||||||||||||||||||||||||||||||||||||||||||
2������ӯ, ���ٺ�.����Ʒ���Ƥ�����ϻ������е�Ӧ��[J]. ����Ƥ���Բ�ѧ��־, 2007,33(6): 334-336 | |||||||||||||||||||||||||||||||||||||||||||||||||
3��������,��ȫ��.�Ƽ�����Ƥ���ϻ����о���չ[J]. ����Ƥ���Բ�ѧ��־, 2008,34(6): 374-376 | |||||||||||||||||||||||||||||||||||||||||||||||||
4���Ŷ��� ������.�Ƽ��ظ�Ԥ���ӻ�Ƥ���ϻ�[J]. ����Ƥ���Բ�ѧ��־, 2009,35(3): 194-196 | |||||||||||||||||||||||||||||||||||||||||||||||||
5����ͮ����, ��������У.Ƥ��˥�ϼ�Ӱ�����ص��о�[J]. ����Ƥ���Բ�ѧ��־, 1996,22(2): 90-93 | |||||||||||||||||||||||||||||||||||||||||||||||||
6�����Ʋ�����, ����������, ��������У.Ƥ����Ȼ˥�ϵķ�������ѧ����[J]. ����Ƥ���Բ�ѧ��־, 1999,25(3): 151-154 | |||||||||||||||||||||||||||||||||||||||||||||||||
7��������, ����.Ƥ��˥�Ϸ�������ѧ���Ƶ��о���չ[J]. ����Ƥ���Բ�ѧ��־, 2003,29(2): 114-117 | |||||||||||||||||||||||||||||||||||||||||||||||||
8��������, �����, ������.������DNAͻ����Ƥ���ϻ�[J]. ����Ƥ���Բ�ѧ��־, 2003,29(3): 173-176 | |||||||||||||||||||||||||||||||||||||||||||||||||
9��������, ������.�����������ƽ�չ[J]. ����Ƥ���Բ�ѧ��־, 2003,29(5): 279-281 | |||||||||||||||||||||||||||||||||||||||||||||||||
10������, Mac-Mary S, Humbert P.����Ƥ���������������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2004,30(5): 291-293 | |||||||||||||||||||||||||||||||||||||||||||||||||
11��������, ������.Ƥ����Ȼ˥�ϼ����ϻ�[J]. ����Ƥ���Բ�ѧ��־, 2004,30(6): 354-356 | |||||||||||||||||||||||||||||||||||||||||||||||||
12������ӯ, ���ٺ�.����Ʒ���Ƥ�����ϻ������е�Ӧ��[J]. ����Ƥ���Բ�ѧ��־, 0,(): 334-336 | |||||||||||||||||||||||||||||||||||||||||||||||||
13�����, ��չ��.����ǿ��Թ��ϻ�����������[J]. ����Ƥ���Բ�ѧ��־, 2007,33(1): 30-32 | |||||||||||||||||||||||||||||||||||||||||||||||||
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