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| PubMed | |
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Article by CAO Hua |
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Article by ZHENG Jie |
UVA1��ӲƤ����Ӧ�ý�չ
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�Ϻ���ͨ��ѧҽѧԺ�������ҽԺƤ����, 200025
ӲƤ����һ���Ծ����Ի�������Ƥ��Ӳ�����������������ά��Ϊ�����Ľ����֯��,Ŀǰ������Ч��ҩ���������Ʒ�.UVAI(340��400nm)��Ϊһ�ֽ��µĹ�ѧ�Ʒ�ΪӲƤ���ṩ���µ������ֶβ���ȡ���˽�Ϊ�������Ч.UVA1����ɴٽ���Ƥ����άϸ���ϻ��ʽ�������ø�ı��,���ƽ�ԭ�ϳ�,������֢ϸ������,���ٴ��ϱ���Ϊԭ��Ӳ����Ƥ����.������,��ѧ�߶Բ�ͬ����UVA1����ӲƤ������Ч�����˹۲첢̽����UVA1����ӲƤ���Ŀ��ܵĻ���.
Application of UVA1 in Scleroderma
Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Scleroderma is a connective disease characterized by localized or diffuse sclerosis of skin and/or fibrosis of various internal organs.Its treatment is difficult and remains a great challenge.Ultraviolet Al (340��400nm) presents a new phototherapy for scleroderma with satisfactory efficiency.UVAl irradiation has been shown to be able to increase the expression of matrix metalloproteinase in dermal fibroblasts,suppress collagen synthesis,reduce inflammatory cell infiltration and to induce the softening of sclerotic lesions.Recently, several studies have evaluated the therapeutic effect of UVA1 irradiation with different doses in the treatment of scleroderma and possible mechanisms in the treatment.
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