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| PubMed | |
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Article by HUANG Kun |
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Article by LIU Hou-jun |
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Article by TU Ya-ting |
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Stat 3 and Related Skin Diseases
Department of Dermatology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China
Department of Dermatology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China
Stat 3 is an important nuclear transcription factor participating in cell proliferation, survival, transformation, migration and other biological processes. It plays a critical role in the pathogenesis of some skin diseases characterized by epidermal hyperproliferation and/or dysdifferentiation,such as psoriasis and skin cancers. The blocking of its function with the introduction of specific reverse oligonucleotide, decoy oligonucleotide or dominant-negative protein into the targeted cells, could inhibit the proliferation and promote the apoptosis of the cells. This article reviews the relation between Stat 3 and the above-mentioned diseases,as well as the role and activation of Stat 3 in the pathogenesis of these diseases.
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