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| PubMed | |
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Article by MEI Ce-fang |
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Article by LIN Bao-zhu |
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��ɽ��ѧ�����ڶ�ҽԺƤ���� ���� 510120
֬���Խǻ����������˳����ı�Ƥ��������,50���80%���ϻ�����������о���Ϊ,�չ��������ͷ��������Ⱦ��ò��ķ����������,��ȷ�л��Ʋ������ò�Ƥ�������ɫ����,�о���Ϊ,�������Ľ����γ�ϸ��������Ƥ�������ں���ϸ�����¡���������ѧ������о����ָò�Ƥ����p53��Bcl-2��p73��p16��������ӱ���쳣,����ϸ���ķֻ�����ֳ��������ϸ����������,�Ӷ����뼲���ķ�����
Advances in Seborrheic Keratosis
Department of Dermatology, Second Affiliated Hospital of Zhongshan University, Guangzhou 510120, China
Department of Dermatology, Second Affiliated Hospital of Zhongshan University, Guangzhou 510120, China
Seborrheic keratosis (SK), usually seen in old people, is an epidermal benign tumor, and more than 80% people over 50 years old suffer from this disease. Recently, it has been shown that the exposure to sunlight and infection with human papilloma virus are closely related to the development of SK, but the exact mechanism is not clear. Most of the SK lesions are deep colored, and researches show that this is because the endothelin secreted by proliferative keratinocytes acts on melanocytes. Studies on molecular biology find that the expression of P53, Bcl-2, P73 and P16 in SK lesions is abnormal, which leads to the disorder of cell differentiation, proliferation, apoptosis and cell cycle, and eventually participate in the occurrence of this disease.
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