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�ؼ����� Ӧ�� ͺ�� | |||||||||||||||||||||||||||||||||||||||||||||
Stress and Hair Loss | |||||||||||||||||||||||||||||||||||||||||||||
Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China | |||||||||||||||||||||||||||||||||||||||||||||
Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China | |||||||||||||||||||||||||||||||||||||||||||||
Abstract:
Stress has long been implicated as one of the causal factors of hair loss. Stress is a primary inducer of telogen effluvium,also an aggravating factor of hair loss (e.g., androgenetic alopecia,alopecia areata)mainly induced by endocritic,infectious,genetic or immunological factors. Depression induced by hair loss may aggravate it and induce a self-perpetuating vicious circle. Besides the drugs, comprehensive and cautious strategies are required to relieve the patients' psychological pressure, which will help to release the stress, block the vicious circle and raise the patients' quality of life. Here we summarize the information about the physiological relationship between stress and hair loss,the way of stress influencing hair growth and the molecular mechanisms of the hair follicles response to stress. | |||||||||||||||||||||||||||||||||||||||||||||
Keywords: Stress Alopecia | |||||||||||||||||||||||||||||||||||||||||||||
�ո����� 2005-11-02 ������ ����淢������ | |||||||||||||||||||||||||||||||||||||||||||||
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[1] Mello Ade A,Mello MF,Carpenter LL,et al.Update on stress and depression:the role of the hypothalamic-pituitary-adrenal (HPA)axis.Rev Bras Psiquiatr,2003,25:231-238. [2] Slominski AT,Botchkarev V,Choudhry M,et al.Cutaneous expression of CRH and CRH-R.Is there a "skin stress response system?".Ann N Y Acad Sci,1999,885:287-311. [3] Kimyai-Asadi A,Usman A.The role of psychological stress in skin disease.J Cutan Med Surg,2001,5:140-145. [4] Paus R,Botchkarev VA,Botchkareva NV,et al.The skin POMC system (SPS).Leads and lessons from the hair follicle.Ann N Y Acad Sci,1999,885:350-363. [5] Botchkarev VA.Stress and the hair follicle:exploring the connections.Am J Pathol,2003,162:709-712. [6] Ito N,Ito T,Kromminga A,et al.Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol.FASEB J,2005,19:1332-1334. [7] Brajac I,Tkalcic M,Dragojevic DM,et al.Roles of stress,stress perception and trait-anxiety in the onset and course of alopecia areata.J Dermatol,2003,30:871-878. [8] Wells PA,Willmoth T,Russell RJ.Does fortune favour the bald?Psychological correlates of hair loss in males.Br J Psychol,1995,86 (Pt 3):337-344. [9] Gulec AT,Tanriverdi N,Duru C,et al.The role of psychological factors in alopecia areata and the impact of the disease on the quality of life.Int J Dermatol,2004,43:352-356. [10] Arck PC,Handjiski B,Peters EM,et al.Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways.Am J Pathol,2003,162:803-814. [11] Aoki E,Shibasaki T,Kawana S.Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice.Exp Dermatol,2003,12:371-377. [12] Arck PC,Handjiski B,Hagen E,et al.Indications for a 'brain-hair follicle axis (BHA)':inhibition of keratinocyte proliferation and up-regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P.FASEB J,2001,15:2536-2538. [13] Peters EM,Kuhlmei A,Tobin DJ,et al.Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin.Brain Behav Immun,2005,19:252-262. [14] Arck PC,Handjiski B,Kuhlmei A,et al.Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition.J Mol Med,2005,83:386-396. [15] Peters EM,Handjiski B,Kuhlmei A,et al.Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor.Am J Pathol,2004,165:259-271. [16] Hadshiew IM,Foitzik K,Arck PC,et al.Burden of hair loss:stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia.J Invest Dermatol,2004,123:455-457. [17] Paus R,Nickoloff BJ,Ito T.A hairy' privilege.Trends Immunol,2005,26:32-40. [18] Arck PC,Handjiski B,Peters EM,et al.Topical minoxidil counteracts stress-induced hair growth inhibition in mice.Exp Dermatol,2003,12:580-590. |
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2������ ���õ�.���ĺ�HPA�������ڰ�ͺ�����е�����[J]. ����Ƥ���Բ�ѧ��־, 2009,35(3): 156-158 | |||||||||||||||||||||||||||||||||||||||||||||
3������ ����.��������Ӧ�����Ƽ����������ƽ�չ[J]. ����Ƥ���Բ�ѧ��־, 2010,36(2): 101-103 | |||||||||||||||||||||||||||||||||||||||||||||
4������, ������.��������������Ӧ����ϸ�����������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2004,30(3): 167-169 | |||||||||||||||||||||||||||||||||||||||||||||
5������Ӣ, ������.���ݿ˵�����Ƥ���������е��о���״[J]. ����Ƥ���Բ�ѧ��־, 2004,30(6): 378-380 | |||||||||||||||||||||||||||||||||||||||||||||
6��������, ����.����������-������ʧ��[J]. ����Ƥ���Բ�ѧ��־, 2007,33(5): 281-283 | |||||||||||||||||||||||||||||||||||||||||||||
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