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| PubMed | |
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Article by XU Wei |
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Article by ZHENG Min |
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Neurotrophins in the Pathogenesis of Atopic Dermatitis
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
Neurotrophins belong to a complex molecular family, and their biologic effects have been found not only restricted to the central nervous system but also relevant to the control of growth and function of nerve cells present in other organs including the skin. More and more studies have demonstrated that neurotrophins play an important role in the pathogenesis of inflammatory skin diseases, such as atopic dermatitis. Although various cells of human skin are proved to be able to produce a series of neurotrophins, a definite relationship between the expression of such mediators and innervation has not been established. Here the advances in the research of neurotrophins in the pathogenesis of atopic dermatitis are summarized.
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