[an error occurred while processing this directive] ����Ƥ���Բ�ѧ��־ 2006, 32(3) 139-141 DOI:     ISSN: 2096-5540 CN: 32-1880/R

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PubMed
Article by QIAN Ge
Article by WANG Qian-qiu
Article by ZHANG Guo-cheng

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Positive Pleiotropic Effects of Statins in the Treatment of Skin Diseases

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China

Abstract:

Statins, lipid-lowering drugs, 3-hydroxy-3-methylgulutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are widely used in the prevention and treatment of atherogenesis and cardiovascular morbidity. Besides, there is growing evidence that statins have many other activities. The novel functions of statins are as follows. 1. They own immunomodulatory activities by scavenging the oxygen free radicals, blocking the chemotaxis of white cells, suppressing the antigen-presenting function, inhibiting the activation of lymphocytes and downregulating the expression of cytokines including adhesion molecules. 2. They can protect endothelial cells, inhibit the formation of thrombus and improve vascular function. 3. They can modulate the collagen metabolism of fibroblasts and exert a strong anti-proliferation activity in many tissues. Given the effects mentioned above, statins may be used as a new medicine to treat many skin diseases.

Keywords: Statins   Immune modulating   Collagen   Metabolism  
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