|
��չ����
|
|
| ������Ϣ | |
 |
Supporting info |
|
PDFȫ�� |
|
[HTMLȫ��] |
|
����� |
| �����뷴�� | |
|
�������ù����� |
|
���� |
|
Email Alert |
|
���·��� |
|
���������Ϣ |
| ���Ĺؼ���������� | |
|
��άA |
|
�ǻ� |
|
��ͯ |
| ��������������� | |
|
��Ȩ |
|
������ |
| PubMed | |
|
Article by LUO Quan |
|
Article by ZHANG Xi-bao |
��άA���ƶ�ͯ�ǻ��Լ������о���״
��Ȩ, ������
������Ƥ���������� 510095
��άAΪ�ڶ���άA��,�ǰ�άA���Ĵ�л������,���нϸߵ��������öȼ��϶̵İ�˥��,�ѹ㷺���Ƹ��ֽǻ���Ƥ����,����Щ�ǻ��Լ���������Ŵ��Լ�������Щ������Ҫ���ڶ�ͯ��������,���,��άA���ͯ��������ǻ��Լ���������Ҫ����ϵ,����άA������������,����ҩ�����������ﵽ��ͯ�ĸ��ࡢ������������ֳϵͳ������һ����DZ�ڲ���Ӱ��,����Ϊ��ҩ���鲻��,�����ҩʱ��������,�ر��ǹ��ڶ����ڶ�ͯ�ǻ��Լ������о����ࡣ
Acitretin in the Treatment of Cutaneous Disorders of Keratinization in Children
Guangzhou Institute of Dermatology, Ghangzhou 510095, China
Guangzhou Institute of Dermatology, Ghangzhou 510095, China
Acitretin is a second generation aromatic retinoid, and is the active metabolite of etretinate. Acitretin has a shorter terminal elimination half-life and higher bioavailability than etretinate. It has been widely used in the treatment of cutaneous disorders of keratinization, most of which are genetic diseases, and mainly occur in children and teenagers. Besides the therapeutic effects, it has underlying side effects on pregnancy, as well as hepatic function, bone growth and reproductive system of children. The lack of experience in the use of acitretin and of researches in cutaneous disorders of keratinization in children also warrants the review of related literature.
�㶫ʡ��Ȼ��ѧ����(04004285)
[2] Saracoglu ZN,Tekin N,Urer SM,et al.Oral acitretin treatment in severe congenital ichthyosis of the neonate.Turk J Pediatr,2002,44:61-64.
[3] Gicquel JJ,Vabres P,Dighiero P.Use of topical cutaneous N-acetylcysteine in the treatment of major bilateral ectropion in an infant with lamellar ichthyosis.J Fr Ophtalmol,2005,28:412.
[4] Chan YC,Tay YK,Tan LK,et al.Harlequin ichthyosis in association with hypothyroidism and juvenile rheumatoid arthritis.Pediatr Dermatol,2003,20:421-426.
[5] Singh S,Bhura M,Maheshwari A,et al.Successful treatment of harlequin ichthyosis with acitretin.Int J Dermatol,2001,40:472.
[6] Al-Khenaizan S.Papillon-Lefevre syndrome:the response to acitretin.Int J Dermatol,2002,41:938-941.
[7] Khandpur S,Reddy BS.Papillon-Lefevre syndrome with pyogenic hepatic abscess:a rare association.Pediatr Dermatol,2001,18:45.
[8] Lee MR,Wong LC,Fischer GO.Papillon-Lefevre syndrome treated with acitretin.Australas J Dermatol,2005,46:199-201.
[9] Pandhi D,Reddy BS.A rare association of epidermal nevus syndrome and ainhum-like digital constrictions.Pediatr Dermatol,2002,19:349-352.
[10] Graham-Brown RA,Chave TA.Acitretin for erythrokeratodermia variabilis in a 9-year-old girl.Pediatr Dermatol,2002,19:510-512.
[11] Taube B,Billeaud C,Labreze C,et al.Sjogren-Larsson syndrome:early diagnosis,dietary management and biochemical studies in two cases.Dermatology,1999,198:340-345.
[12] Kirby B,Watson R.Pityriasis rubra pilaris treated with acitretin and narrow-band ultraviolet B (Re-TL-01).Br J Dermatol,2000142:376-377.
[13] Katta R,Reed J,Wolf JE.Comifying Darier's disease.Int J Dermatol,2000,39:844-845.
[14] Paige DG,Judge MR,Shaw DG,et al.Bone changes and their significance in children with ichthyosis on long-term etretinate therapy.Br J Dermatol,1992,127:387-391.
[15] Mork NJ,Kolbenstvedt A,Austad J.Efficacy and skeletal side effects of two years' acitretin treatment.Acta Derm Venereol,1992,72:445-448.