|
��չ����
|
|
| ������Ϣ | |
 |
Supporting info |
|
PDFȫ�� |
|
[HTMLȫ��] |
|
����� |
| �����뷴�� | |
|
�������ù����� |
|
���� |
|
Email Alert |
|
���·��� |
|
���������Ϣ |
| ���Ĺؼ���������� | |
|
������ |
|
ϸ������ |
|
Ƥ������ |
| ��������������� | |
|
���� |
|
����Ⱥ |
|
κ־ƽ |
| PubMed | |
|
Article by ZHOU Lin |
|
Article by LIU Yan-qun |
|
Article by WEI Zhi-ping |
��������Ƥ����������Ե��о���չ
����, ����Ⱥ, κ־ƽ
����ҽѧԺ����ҽԺƤ���Բ��� 221000
�����ػ����ǵ������Ƶ������³�Ա,����ṹ��Ϊ����,����ѡ���Ե��������б��,������ĩ�ֻ���֯�в����,��Ƥ���۰������Ժ�������Ԥ��ָ��;���������������ٽ�����Ƥ����������ϸ����������,��������֯������Ӱ��,������Ϊ�����������������Ƶ��°е㡣
Relationship Between Survivin and Cutaneous Tumors
Department of Dermotovenereology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu, China
Department of Dermotovenereology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, Jiangsu, China
Survivin is a novel member of the inhibitor of apoptosis protein families. Because of its special structure and distribution, that is, it only expresses in tumor tissues and cannot be found in normal terminally differentiated tissues, survivin is an indicator of prognosis for skin squamous cell carcinoma and malignant melanoma. Furthermore, the inhibition of its expression can induce the apoptosis of malignant tumor cells significantly, and has no impact on normal tissues. It is hopeful for survivin to become a valuable mark and a new therapeutic target of tumors.
[2] Krieg A,Mahotka C,Krieg T,et al.Expression of different survivin variants in gastric carcinomas:first clues to a role of survivin-2B in tumour progression.Br J Cancer,2002,86:737-743.
[3] Conway EM,Pollefeyt S,Cornelissen J,et al.Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions.Blood,2000 95:1435-1442.
[4] Suzuki A,Ito T,Kawano H,et al.Survivin initiates procaspase 3/p21complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death.Oncogene,2000,19:1346-1353.
[5] Kallio M J,Nieminen M,Eriksson JE.Human inhibitor of apoptosis protein (IAP) survivin participates in regulation of chromosome segregation and mitotic exit.FASEB J,2001,15:2721-2723.
[6] O' Connor DS,Schechner JS,Adida C,et al.Control of apoptosis during angiogenesis by survivin expression in endothelial cells.Am J Pathol,2000,156:393-398.
[7] Hoffman WH,Biade S,Zilfou JT,et al.Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.J Biol Chem,2002,277:3247-3257.
[8] Mirza A,McGuirk M,Hockenberry TN,et al.Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway.Oncogene,2002,21:2613-2622.
[9] Lo Muzio L,Pannone G,Staibano S,et al.Survivin expression in oral squamous cell carcinoma.Br J Cancer,2003,89:2244-2248.
[10] Gradilone A,Gazzaniga P,Ribuffo D,et al.Survivin,bcl-2,bax,and bcl-X gene expression in sentinel lymph nodes from melanoma patients.J Clin Oncol,2003,21:306-312.
[11] Park HR,Min SK,Cho HD,et al.Expression profiles of p63,p53,survivin,and hTERT in skin tumors.J Cutan Pathol,2004,31:544-549.
[12] Silver SG,Crawford RI.Fatal squamous cell carcinoma arising from transplant-associated porokeratosis.J Am Acad Dermatol,2003,49:931-933.
[13] Arranz-Salas I,Sanz-Trelles A,Ojeda DB.p53 alterations in porokeratosis.J Cutan Pathol,2003,30:455-458.
[14] Bowen AR,Hanks AN,Murphy KJ,et al.Proliferation,apoptosis,and survivin expression in keratinocytic neoplasms and hyperplasias.,Am J Dermatopathol,2004,26:177-181.
[15] Lu B,Makhija SK,Nettelbeck DM,et al.Evaluation of tumor-specific promoter activities in melanoma.Gene Ther,2005,12:330.
[16] Coughlin CM,Vance BA,Grupp SA,et al.RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets:implications for pediatric immunotherapy.Blood,2004,103:2046-2054.
[17] Shinozawa I,Inokuchi K,Wakabayashi I,et al.Disturbed expression of the anti-apoptosis gene,survivin,and EPR-1 in hematological malignancies.euk Res,2000,4:965-970.
[18] Kanwar JR,Shen WP,Kanwar RK,et al.Effects of survivin antagonists on growth of established tumors and B7-1 immunogene therapy.J Natl Cancer Inst,2001,93:1541-1552.
[19] Grossman D,Kim PJ,Blanc-Brude OP,et al.Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.J Clin Invest,2001,108:991-999.
[20] Mesri M,Wall NR,Li J,et al.Cancer gene therapy using a survivin mutant adenovirus.J Clin Invest,2001,108:981-990.
[21] Reker S,Meier A,Holten-Andersen L,et al.Identification of novel survivin-derived CTL epitopes.Cancer Biol Ther,2004,3:173-179.
[22] Grossman D,Altieri DC.Drug resistance in melanoma:mechanisms,apoptosis,and new potential therapeutic targets.Cancer Metastasis Rev,2001,20:3-11.
[23] Allen SM,Florell SR,Hanks AN,et al.Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression.Cancer Res,2003,63:567-572.