[an error occurred while processing this directive] ����Ƥ���Բ�ѧ��־ 2006, 32(2) 102-104 DOI:     ISSN: 2096-5540 CN: 32-1880/R

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PubMed
Article by CHEN Bing
Article by LIAN Cui-hong
Article by LIU Wei-da

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Virulence Factors of Candida albicans

Department of Dermatology, the Second People's Hospital of Shenzhen, Shenzhen 518035, Guangdong, China

Department of Dermatology, the Second People's Hospital of Shenzhen, Shenzhen 518035, Guangdong, China

Abstract:

Candida albicans is an important human fungal pathogen. We review the virulence factors of Candida albicans and their identification. The factors include adhesion molecules, enzymes for invasion, and factors responsible for morphogenesis and phenotypic switching of Candida albicans, etc. They may be detected by Ura-blaster methodology, gene splitting, analysis of gene function with systematic approaches and search of genes potentially related to virulence by differential-display reverse transcription polymerase chain reaction.

Keywords: Candida albicans   Virulence factors  
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[1] Hoyer LL.The ALS gene family of Candida albicans.Trends Microbiol,2001,9:176-180.
[2] Fu Y,Ibrahim AS,Sheppard DC,et al.Candida albicans Alslp:an adhesin that is a downstream effector of the EFG1 filamentation pathway.Mol Microbiol,2002,44:61-72.
[3] Tsuchimori N,Sharkey LL,Fonzi WA,et al.Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells.Infect Immun,2000,68:1997-2002.
[4] Sundstrom P,Balish E,Allen CM.Essential role of the Candida albicans transglutaminase substrate,hyphal wall protein 1,in lethal oroesophageal candidiasis in immunodeficient mice.J Infect Dis,2002,185:521-530.
[5] Munro CA,Bates S,Buurman ET,et al.Mntlp and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence.J Biol Chem,2005,280:1051-1060.
[6] Ghannoum MA.Potential role of phospholipases in virulence and fungal pathogenesis.Clin Microbiol Rev,2000,13:122-143.
[7] Dolan JW,Bell AC,Hube B,et al.Candida albicans PLDI activity is required for full virulence.Med Mycol,2004,42:439-447.
[8] Schaller M,Korting HC,Borelli C,et al.Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis.Infect Immun,2005,73:2758.
[9] Chen YC,Wu CC,Chung WL,et al.Differential secretion of Sap4-6proteins in Candida albicans during hyphae formation.Microbiology,2002,148:3743-3754.
[10] Taylor BN,Staib P,Binder A,et al.Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection.Infect Immun,2005,73:1828-1835.
[11] Lengeler KB,Davidson RC,D' souza C,et al.Signal transduction cascades regulating fungal development and virulence.Microbiol Mol Biol Rev,2000,64:746-785.
[12] McNemar MD,Fonzi WA.Conserved serine/threonine kinase encoded by CBK1 regulates expression of several hypha-associated transcripts and genes encoding cell wall proteins in Candida albicans.J Bacteriol,2002,184:2058-2061.
[13] Richard M,Ibata-Ombetta S,Dromer F,et al.Complete glycosylphosphatidylinositol anchors are required in Candida albicans for full morphogenesis,virulence and resistance to macrophages.Mol Microbiol,2002,44:841-853.
[14] Hwang CS,Oh JH,Huh WK,et al.Ssn6,an important factor of morphological conversion and virulence in Candida albicans.Mol Microbiol,2003,47:1029-1043.
[15] Zheng X,Wang Y,Wang Y.Hgcl,a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.EMBO J,2004,23:1845-1856.
[16] Zhao R,Lockhart SR,Daniels K,et al.Roles of TUP1 in switching,phase maintenance,and phase-specific gene expression in Candida albicans.Eukaryot Cell,2002,1:353-365.
[17] Staab JF,Sundstrom P.URA3 as a selectable marker for disruption and virulence assessment of Candida albicans genes.Trends Microbiol,2003,11:69-73.
[18] Michel S,Ushinsky S,Klebl B,et al.Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes.Mol Microbiol,2002,46:269-280.
[19] Park JY,Kim DH,Shin WS,et al.Search for genes potentially related to germ tube formation in Candida albicans by differential-display reverse transcription polymerase chain reaction.Yonsei Med J,2003,44:110-118.
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6��������, ������, ��ά��.��������������в�ѧ��չ[J]. ����Ƥ���Բ�ѧ��־, 2004,30(3): 185-187
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