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| PubMed | |
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Article by WANG Kai-li |
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Article by ZHANG Hong |
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Aspartyl Proteinases Secreted by Candida albicans
Department of Dermatology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
Department of Dermatology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
Candidiasis is a common mycosis, most of which is caused by the opportunistic fungal pathogen, Candida albicans. Secreted aspartyl proteinase is one of the important virulence factors of Candida albicans. Now we summarize the biochemical characteristics of the proteinase, the expression and regulation of its encoding genes and the interaction between Candida albicans and the host, in order to help better understand the pathogenic mechanism of Candida albicans and develop a new treatment for candidiasis.
[2] Ripeau JS,Fiorillo M,Aumont F,et al.Evidence for differential expression of Candida albicans virulence genes during oral infection in intact and human immunodeficiency virus type 1-transgenic mice.J Infect Dis,2002,185:1094-1102.
[3] Naglik JR,Rodgers CA,Shirlaw P J,et al.Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections.J Infect Dis,2003,188:469-479.
[4] Felk A,Kretschmar M,Albrecht A,et al.Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4to Sap6 are required for the invasion ofparenchymal organs.Infect Immun,2002,70:3689-3700.
[5] Staib P,Kretschmar M,Nichterlein T,et al.Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene.Mol Microbiol,2002,44:1351-1366.
[6] Tavanti A,Pardini G,Campa D,et al.Differential expression of secretory aspartyl proteinase genes (SAP1-10) in oral Candida albicans isolates with distinct karyotypes.J Clin Microbiol,2004,42:4726-4734.
[7] Chen YC,Wu CC,Chung WL,et al.Differential secretion of Sap4-6proteins in Candida albicans during hyphae formation.Microbiology,2002,148(Pt 11):3743-3754.
[8] Korting HC,Hube B,Oberbauer S,et al.Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efgl mutant is associated with attenuated virulence during infection of oral epithelium.J Med Microbiol,2003,52 (Pt 8):623-632.
[9] Staib P,Kretschmar M,Nichterlein T,et al.Transcriptional regulators Cphlp and Efglp mediate activation of the Candida albicans virulence gene SAP5 during infection.Infect Immun,2002,70:921-927.
[10] Schweizer A,Rupp S,Taylor BN,et al.The TEA/ATTS transcription factor CaTeclp regulates hyphal development and virulence in Candida albicans.Mol Microbiol,2000,38:435-445.
[11] Staib P,Binder A,Kretschmar M,et al.Teclp-independent activation of a hypha-associated Candida albicans virulence gene during infection.Infect Immun,2004,72:2386-2389.
[12] Murad AM,d'Enfert C,Gaillardin C,et al.Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTupl,CaMigl and CaNrgl.Mol Microbiol,2001,42:981-993.
[13] Kitanovic A,Nguyen M,Vogl G,et al.Phosphatidylinositol 3-kinase VPS34 of Candida albicans is involved in filamentous growth,secretion of aspartic proteases,and intracellular detoxification.FEMS Yeast Res,2005,5:431-439.
[14] Hube B,Naglik J.Candida albicans proteinases:resolving the mystery of a gene family.Microbiology,2001,147 (Pt 8):1997-2005.
[15] Bektic J,Lell CP,Fuchs A,et al.HIV protease inhibitors attenuate adherence of Candida albicans to epithelial cells in vitro.FEMS Immunol Med Microbiol,2001,31:65-71.
[16] Kretschmar M,Felk A,Staib P,et al.Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice.Microb Pathog,2002,32:61-70.