|
��չ����
|
|
| ������Ϣ | |
 |
Supporting info |
|
PDFȫ�� |
|
[HTMLȫ��] |
|
����� |
| �����뷴�� | |
|
�������ù����� |
|
���� |
|
Email Alert |
|
���·��� |
|
���������Ϣ |
| ���Ĺؼ���������� | |
|
����Ī˾ |
|
Ƥ������ |
|
���� |
| ��������������� | |
|
������ |
| PubMed | |
|
Article by GU You-shou |
�ֲ���������Ī˾����Ƥ����
������
�㶫ʡƤ���Բ���������, ����510500
����Ī˾��һ�ִ��������������Ƽ�,�����û����뻷��������,ȫ��Ӧ����Ҫ����Ԥ������������ֲ���ųⷴӦ�Լ����������Լ������뻷���ز�ͬ����,��������Է���������Խ�С,���Դ���Ƥ����,Ϊ����ȫ������Ӧ�ķ���,���Ƴ������Ƽ����Ƹ��������Ժ�����Ƥ������
Topical Application of Tacrolimus in Skin Diseases
Guangdong Provincial Centers for Skin Diseases and STIs Control and Prevention, Guangzhou 510500, China
Guangdong Provincial Centers for Skin Diseases and STIs Control and Prevention, Guangzhou 510500, China
Tacrolimus is a macrolide immunosupressant. The mechanism of its action is similar to that of cy-closporine. Systemic tacrolimus is mostly used in the prevention of rejection after organ transplantation and in the treatment of immune diseases. Since the molecular weight of tacrolimus is low, it can penetrate the epidermal barrier, which is different from cyclosporine. In order to avoid systemic side effects, topical agents of tacrolimus have been manufactured for the treatment of immune and inflammatory dermatoses. This article reviews the topical use of tacrolimus ointment in the treatment of skin diseases.
[2] Won CH,Seo PG,Park YM,et al.A multicenter trial of the efficacy and safety of 0.03% tacrolimus ointment for atopic dermatitis in Korea.J Dermatolog Treat,2004,15:30-34.
[3] Paller AS,Lebwohl M,Fleischer AB Jr,et al.Tacrolimus ointment is more effective than pimecrolimus cream with a similar safety profile in the treatment of atopic dermatitis:results from 3 randomized,comparative studies.J Am Acad Dermatol,2005,52:810-822.
[4] Lebwohl M,Freeman AK,Chapman MS,et al.Tacrolimus ointment is effective for facial and intertriginous psoriasis.J Am Acad Dermatol,2004,51:723-730.
[5] Rozycki TW,Rogers RS 3rd,Pittelkow MR,et al.Topical tacrolimus in the treatment of symptomatic oral lichen planus:a series of 13 patients.J Am Acad Dermatol,2002,46:27-34.
[6] Kaliakatsou F,Hodgson TA,Lewsey JD,et al.Management of recalcitrant ulcerative oral lichen planus with topical tacrolimus.J Am Acad Dermatol,2002,46:35-41.
[7] Thomson MA,Hamburger J,Stewart DG,et al.Treatment of erosive oral lichen planus with topical tacrolimus.J Dermatolog Treat,2004,15:308-314.
[8] Lyon CC,Smith A J,Beck MH,et al.Parastomal pyoderma gangrenosum:clinical features and management.J Am Acad Dermatol,.2000,42:992-1002.
[9] Petering H,Kiehl P,Breuer C,et al.Pyoderma gangrenosum:successful topical therapy with tacrolimus (FK506).Hautarzt,2001,52:47.
[10] Goldman D.Tacrolimus ointment for the treatment of steroid-induced rosacea:a preliminary report.J Am Acad Dermatol,2001,44:995-998.
[11] Bamford JT,Elliott BA,Haller IV.Tacrolimus effect on rosacea.J Am Acad Dermatol,2004,50:107-108.
[12] Assmann T,Becker-Wegerich P,Grewe M,et al.Tacrolimus ointment for the treatment of vulvar lichen sclerosus.J Am Acad Dermatol,2003,48:935-937.
[13] Hollar CB,Jorizzo JL.Topical tacrolimus 0.1% ointment for refractory skin disease in dermatomyositis:a pilot study.J Dermatolog Treat,2004,15:35-39.
[14] Druke A,Gambichler T,Altmeyer P,et al.0.1% Tacrolimus ointment in a patient with subacute cutaneous lupus erythematosus.J Dermatolog Treat,2004,15:63-64.
[15] Grimes PE,Morris R,Avaniss-Aghajani E,et al.Topical tacrolimus therapy for vitiligo:therapeutic responses and skin messenger RNA expression of proinflammatory cytokines.J Am Acad Dermatol,2004,51:52-61.
[16] Silverberg NB,Lin P,Travis L,et al.Tacrolimus ointment promotes repigmentation of vitiligo in children:a review of 57 cases.J Am Acad Dermatol,2004,51:760-766.
[17] Kawaguchi M,Mitsuhashi Y,Kondo S.Successful treatment of eosinophilic pustular folliculitis with topical tacrolimus.Int J Dermatol,2004,43:608-610.
[18] Suga Y,Tsuboi R,Hashimoto Y,et al.A case of ichthyosis linearis circumflexa successfully treated with topical tacrolimus.J Am Acad Dermatol,2000,42:520-522.
[19] Choi CJ,Nghiem P.Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease:a case series of 18 patients.Arch Dermatol,2001,137:1202-1206.
[20] Shaw DW,Eichenfield LF,Shainhouse T,et al.Allergic contact dermatitis from tacrolimus.J Am Acad Dermatol,2004,50:962.
[21] Williams HC.Clinical practice.Atopic dermatitis.N Engl J Med,2005,352:2314-2324.
[22] Allen A,Siegfried E,Silverman R,et al.Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome.Arch Dermatol,2001,137:747-750.