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Article by ZHOU Bing-rong |
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Article by LUO Dan |
Toll��������Ƥ������Ⱦ����
�ܱ���, �浤
�Ͼ�ҽ�ƴ�ѧ��һ����ҽԺƤ����, 210029
��Ȼ���߷���Toll��������һ���㷺���������桢�������ֲ�������и߶ȱ��ض����ϵļ��塣��������Ȼ�����пɷ�����Ҫ�Ŀ���Ⱦ���߹���,�����������ܡ������Կ���Ⱦ����,�Լ�һЩ������������ԡ��о�Toll��������Ƥ����֯��ʶ��͵��������ļ���ϸ������������������еĻ���,ͨ����Toll�����弰������ϵͳ����ʶ��Ϊ���θ���Ƥ����Ⱦ�Լ������ٹ���ǰ����
Toll-like Receptors and Anti-infective Immunity in Skin
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Toll-like receptors(TLRs) are a kind of innate immunity receptor and belong to an archaic and highly conservative receptor family. They express widely in insects, vertebrates and plant cells. They are crucial participants in the innate immune responses, and are closely related to immunologic tolerance, specific anti-infective immunity and some other diseases. This article reviews the mechanisms of the recognition of and defense against some conventional bacteria, viruses and fungi by Toll-like receptors. The understanding of Toll-like receptors and TLR signaling system will lay a broad way to prevent and treat various infectious dermatoses.
[2] Lien E,Ingalls RR.Toll-like receptors.Crit Care Med,2002,30(1 Supp):S1-S11.
[3] Kang TJ,Lee SB,Chae GT.A polymorphism in the toll-like receptor2 is associated with IL-12 production from monocyte in lepromatous leprosy.Cytokine,2002,20:56-62.
[4] McCoy SL,Kurtz SE,Macarthur C J,et al.Identification of a peptide derived from vaccinia virus A52R protein that inhibits cytokine secretion in response to TLR-dependent signaling and reduces in vivo bacterial-induced inflammation.J Immunol,2005,174:3006-3014.
[5] Dai J,Megjugorac NJ,Amrute SB,et al.Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells.J Immunol,2004,173:1535-1548.
[6] Lund JM,Alexopoulou L,Sato A,et al.Recognition of singlestranded RNA.viruses by Toll-like receptor 7.Proc Natl Acad Sci U S A,2004,101:5598-5603.
[7] Bieback K,Lien E,Klagge IM,et al.Hemagglutinin protein of wildtype measles virus activates toll-like receptor 2 signaling.J Virol,2002,76:8729-8736.
[8] Malmgaard L,Melchjorsen J,Bowie AG,et al.Viral activation of macrophages through TLR-dependent and-independent pathways.J Immunol,2004,173:6890-6898.
[9] Ashkar AA,Yao XD,Gill N,et al.Toll-like receptor (TLR)-3,but not TLR4,agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA.J Infect Dis,2004,190:1841-1849.
[10] Wenzel J,Uerlich M,Haller O,et al.Enhanced type I interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with the TLR7-agonist imiquimod.J Cutan Pathol,2005,32:257-262.
[11] Netea MG,Van Der Graaf CA,Vonk AG,Verschueren I,et al.The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis.J Infect Dis,2002,185:1483.
[12] Roeder A,Kirschning CJ,Schaller M,et al.Induction of nuclear factor-kappa B and c-Jun/activator protein-1 via toll-like receptor 2 in macrophages by antimycotic-treated Candida albicans.J Infect Dis,2004,190:1318-1326.
[13] Meier A,Kirschning CJ,Nikolaus T,et al.Toll-like receptor (TLR)2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages.Cell Microbiol,2003,5:561-570.
[14] Netea MG,Warris A,Van der Meer JW,et al.Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction.J Infect Dis,2003,188:320-326.