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| PubMed | |
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Article by CHEN Sheng-li |
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Article by SUN Jian-fang |
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Epidermolysis Bullosa Acquisita:Diagnosis and Management
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
Epidermolysis bullosa acquisita(EBA) is a chronic subepidermal autoimmune bullous disease of skin and mucosa characterized by the presence of circulating autoantibodies to the type VII collagen within the anchoring fibrils of the basement membrane zone. EBA is classified into two subsets: classic and inflammatory. Inaddition to clinical investigations and usual laboratory tests such as the histopathology examination, direct immunofluorescence and indirect immunofluorescence, other special tests, including salt-split skin immunofluor-escence, Western blot analysis, immunoelectron microscopy, and enzyme-linked immunosorbent assay, are necessary for the diagnosis of EBA and differential diagnosis of it from other autoimmune bullous diseases. EBA is refractory to many treatments. Systemic corticosteroids, immunosuppressive drugs and other anti-inflammatory drugs will be helpful.
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