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| PubMed | |
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Article by WANG Xiao-hua |
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Article by XU Li-xian |
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Article by LUO Dan |
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Article by Yang Jun-wei |
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�Ͼ�ҽ�ƴ�ѧ��һ����ҽԺ���ڿ�, 210029
��Դ����ά��ӲƤ���ǽ������·��ֵ�һ��Ƥ�������ò���ӲƤ�����ٴ����ֺ�����,�����Ծ�����Ƥ��Ӳ��Ϊ��ҪƤ����֡�����֯��������:��Ƥ����CD34������ϸ����ֳ��������չ��Ƥ��֬����֯,����𤵰�͵�����ά������Ӳ��鵯����֯���;��ԭ��Ⱦɫ�ɼ���Ƥdz������𤵰�׳�����
Nephrogenic Fibrosing Dermopathy
Derpartment of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Derpartment of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Nephrogenic fibrosing dermopathy (NFD) is a newly recognized fibrosing skin condition. Its primary clinical manifestation is localized sclerosis of the skin, which is very similar to scleroderma. It has characteristic histopathological changes. The skin-biopsy specimen shows a proliferation of CD34-expressing dermal fibrocytic spindle-cells which extend into subcutaneous fat, a slight increase of interstitial mucin and elongated elastic fibers with elastolysis. A colloidal iron stain reveals the deposition of a small amount of mucin in the superficial dermis. The mechanism of the disorder is unclear, but it is known to all that it mostly develops in patients with renal insufficiency, maybe this clue can help us to find the correct cause.
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