[an error occurred while processing this directive] ����Ƥ���Բ�ѧ��־ 2006, 32(1) 32-34 DOI:     ISSN: 2096-5540 CN: 32-1880/R

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PubMed
Article by DONG Zheng-bang
Article by ZHANG Mei-hua

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Mouse Models for Atopic Dermatitis

Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Abstract:

Atopic dermatitis(AD) is a chronic skin disease. The development and establishment of animal models is of great importance for the investigation of the pathogenesis and treatment of AD. Recently, in addition to NC/Nga mice, other mouse models for AD have been developed by gene knockouts, transgenes and haptens. These models will facilitate the research on AD.

Keywords: Dermatitis, atopic   Model, animal   DS-Nh mice   Antigens  
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[1] Leung DY,Boguniewicz M,Howell MD,et al.New insights into atopic dermatitis.J Clin Invest,2004,113:651-657.
[2] Leung DY,Bieber T.Atopic dermatitis.Lancet,2003,361:151-160.
[3] Shiohara T,Hayakawa J,Mizukawa Y.Animal models for atopic dermatitis:are they relevant to human disease? J Dermatol Sci,2004,36:1-9.
[4] Sugiura K,Hiramoto K,Shamoto M,et al.Immunological cell situation in the skin of atopic model mice.J Eur Acad Dermatol Venereol,2004,18:148-152.
[5] Hashimoto Y,Kaneda Y,Akashi T,et al.Persistence of Staphylococcus aureus colonization on the skin of NC/Nga mice.J Dermatol Sci,2004,35:143-150.
[6] Matsuoka H,Maki N,Yoshida S,et al.A mouse model of the atopic eczema/dermatitis syndrome by repeated application of a crude extract of house-dust mite Dermatophagoides farinae.Allergy,2003,58:139-145.
[7] Kohara Y,Tanabe K,Matsuoka K,et al.A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9.Immunogenetics,2001,53:15-21.
[8] Hikita I,Yoshioka T,Mizoguchi T,et al.Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions:another possible model for atopic dermatitis.J Dermatol Sci,2002,30:142-153.
[9] Watanabe A,Takeuchi M,Nagata M,et al.Spontaneous development of dermatitis in DS-Nh mice under specific pathogen-free conditions.Exp Anim,2003,52:77-80.
[10] Watanabe A,Takeuchi M,Nagata M,et al.Role of the Nh (Nonhair) mutation in the development of dermatitis and hyperproduction of IgE in DS-Nh mice.Exp Anim,2003,52:419-423.
[11] Matsukura S,Aihara M,Hirasawa T,et al.Effects of TNCB sensitization in DS-Nh mice,serving as a model of atopic dermatitis,in comparison with NC/Nga mice.Int Arch Allergy Immunol,2005,136:173-180.
[12] Kitagaki H,Fujisawa S,Watanabe K,et al.Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice.J Invest Dermatol,1995,105:749-755.
[13] Matsumoto K,Mizukoshi K,Oyobikawa M,et al.Establishment of an atopic dermatitis-like skin model in a hairless mouse by repeated elicitation of contact hypersensitivity that enables to conduct functional analyses of the stratum,corneum with various non-invasive biophysical instruments.Skin Res Technol,2004,10:122.
[14] Spergel JM,Mizoguchi E,Brewer JP,et al.Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.J Clin Invest,1998,101:1614-1622.
[15] Laouini D,Kawamoto S,Yalcindag A,et al.Epicutaneous sensitization with superantigen induces allergic skin inflammation.J Allergy Clin Immunol,2003,112:981-987.
[16] Takeshita K,Yamasaki T,Akira S,et al.Essential role of MHC II-independent CD4+ T cells,IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.Int Immunol,2004,16:685-695.
[17] Li XM,Kleiner G,Huang CK,et al.Murinemodel of atopic dermatitis associated with food hypersensitivity.J Allergy Clin Immunol,2001,107:693-702.
[18] Chan LS,Robinson N,Xu L.Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease:an experimental animal model to study atopic dermatitis.J Invest Dermatol,2001,117:977-983.
[19] Chen L,Martinez O,Overbergh L,et al.Early up-regulation of Th2 cytokines and late surge of Thl cytokines in an atopic dermatitis model.Clin Exp Immunol,2004,138:375-387.
[20] Konishi H,Tsutsui H,Murakami T,et al.IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.Proc Natl Acad Sci U S A,2002,99:11340-11345.
[21] Yagi R,Nagai H,Iigo Y,et al.Development of atopic dermatitislike skin lesions in STAT6-deficient NC/Nga mice.J Immunol,2002,168:2020-2027.
[22] Spergel JM,Mizoguchi E,Oettgen H,et al.Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.J Clin Invest,1999,103:1103-1111.
[23] Laouini D,Alenius H,Bryce P,et al.IL-10 is critical for Th2 responses in a murine model of allergic dermatitis.J Clin Invest,2003,112:1058-1066.
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1��������,������.��Ӧ��Ƥ��С��ģ���о���չ[J]. ����Ƥ���Բ�ѧ��־, 2006,32(1): 32-
2������,֣��.��Ӫ��������Ӧ��Ƥ�׷������ƵĽ�չ[J]. ����Ƥ���Բ�ѧ��־, 2006,32(3): 165-
3��ף��, ���촺, �׽�.��Ӧ��Ƥ���������Ƶ��о���չ[J]. ����Ƥ���Բ�ѧ��־, 0,(): 369-371
4�����, ����.�ʴ�ϸ������Ӧ��Ƥ�׷����е��о���չ[J]. ����Ƥ���Բ�ѧ��־, 2007,33(6): 372-374
5���,����.Th17ϸ������Ӧ��Ƥ��[J]. ����Ƥ���Բ�ѧ��־, 2008,34(6): 376-378
6�������� ���л�.��Ӧ��Ƥ��ijЩ����ѧ��չ[J]. ����Ƥ���Բ�ѧ��־, 2009,35(5): 309-311
7���ϋ�.ʳ��������ͯ��Ӧ��Ƥ������Լ������[J]. ����Ƥ���Բ�ѧ��־, 2010,36(6): 334-336
8���ӻ�, ����.����ϩ����Ӧ��Ƥ��[J]. ����Ƥ���Բ�ѧ��־, 0,(): 299-301
9����ͮ����, �ィ����У.����ԭ����Ӧ��Ƥ��[J]. ����Ƥ���Բ�ѧ��־, 2000,26(2): 72-75
10����ӥ, ���촺.��Ӧ��Ƥ�ײ��򼰷������Ƶ��о���չ[J]. ����Ƥ���Բ�ѧ��־, 2002,28(3): 154-157
11����ܲ��, ����.P��������Ӧ��Ƥ�׷��������еĵ�λ[J]. ����Ƥ���Բ�ѧ��־, 2002,28(3): 157-159
12������ƽ, ������.��Ӧ��Ƥ�׶���ģ��NC/Nga��ķ������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2003,29(1): 22-24
13��������, ��ѧ��.��Ӧ��Ƥ�׵Ļ�������[J]. ����Ƥ���Բ�ѧ��־, 2003,29(2): 91-93
14���ƺ���, ��ά��, ����.�׽���12����Ӧ��Ƥ��[J]. ����Ƥ���Բ�ѧ��־, 2003,29(3): 170-172
15�������, ��ά��.������Ŵ���Ƥ�������Ŵ��׸����о���չ[J]. ����Ƥ���Բ�ѧ��־, 2003,29(4): 230-233
16������, ����÷, ��־ǿ.��������������Ƥ����̬��Ӧ[J]. ����Ƥ���Բ�ѧ��־, 2003,29(5): 302-306
17���ܾ�, �ĺ�Ȫ.��ͻ״ϸ������Ӧ��Ƥ��[J]. ����Ƥ���Բ�ѧ��־, 2004,30(1): 32-34
18�����Ʒ�, ���л�.��Ӧ��Ƥ�����������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2004,30(5): 300-302
19������, �·�.��Ӧ��Ƥ�׵��о���״[J]. ����Ƥ���Բ�ѧ��־, 2005,31(2): 84-86
20������, �º���, �ź�.����ɫ������Ӧ��Ƥ��[J]. ����Ƥ���Բ�ѧ��־, 2005,31(3): 192-194
21����С��, ��ѧ��, ��ɭ.��Ӧ��Ƥ�׷������Ƶ��о���չ[J]. ����Ƥ���Բ�ѧ��־, 2005,31(4): 215-217
22���ӻ�, ����.����ϩ����Ӧ��Ƥ��[J]. ����Ƥ���Բ�ѧ��־, 0,(): 299-301
23������, ֣��.��Ӫ��������Ӧ��Ƥ�׷������ƵĽ�չ[J]. ����Ƥ���Բ�ѧ��־, 2006,32(3): 165-167
24��Ϳ����, ������.�����γ�ϸ���ڱ�Ӧ�ԽӴ���Ƥ�׺���Ӧ��Ƥ���е�����[J]. ����Ƥ���Բ�ѧ��־, 2006,32(6): 371-373
25��ף��, ���촺, �׽�.��Ӧ��Ƥ���������Ƶ��о���չ[J]. ����Ƥ���Բ�ѧ��־, 2007,33(6): 369-371
26�����, ����.�ʴ�ϸ������Ӧ��Ƥ�׷����е��о���չ[J]. ����Ƥ���Բ�ѧ��־, 0,(): 372-374
27���ӻ�, ����.����ϩ����Ӧ��Ƥ��[J]. ����Ƥ���Բ�ѧ��־, 2005,31(5): 299-301
28������, �ィ��.��Ӧԭ�������������Ƽ�������Ӧ��Ƥ���е�����[J]. ����Ƥ���Բ�ѧ��־, 2007,33(2): 75-77

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