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��Ƥ��Բ�ѧ��־ 2006, 32(1) 29-31 DOI: ISSN: 2096-5540 CN: 32-1880/R

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	PubMed
	Article by HAN Feng-xian
	Article by XU Li-min

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The Relationship between CLA+T Lymphocytes and Psoriasis

Tianjin Changzheng Hospital, Tianjin 300021, China

Abstract:

Cutaneous lymphocyte-associated antigen(CLA) is a special adhesion molecule expressed on the surface of T lymphocytes and also a skin-homing receptor on memory T lymphocytes. Psoriasis is an immune-mediated skin disease with abnormal T cells, which play an important role in the pathogenesis of this disease. CLA, expressed by activated T cells, can accelerate the homing of T lymphocytes to the skin, which is important to the occurrence, development and relapse of psoriasis. The study on the relationship between CLA and psoriasis can help us to understand the importance of abnormal T cells in the pathogenesis of psoriasis, and also may find new targets for the treatment of psoriasis.

Keywords: Psoriasis CLA T-lymphocyte Receptors, lymphocyte homing

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