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PubMed
Article by LI Kai
Article by DUAN Yi-qun
Article by ZHOU Xiao-yong
Article by SHI Ping-rong

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Human Papilloma Virus, Ultraviolet and Skin Tumors

Wuhan No.1 Hospital, Wuhan 430030, China

Wuhan No.1 Hospital, Wuhan 430030, China

Abstract:

Human papillomavirus (HPV) is closely related to many skin cancers and some diseases which possess the possibility of developing skin cancers later(such as epidermodysplasia verruciformis). HPV is often found in most lesions of these diseases. Ultraviolet(UV) radiation is, undoubtedly, a carcinogenic factor. Some recent researches indicate UV has something to do with the prevalence of HPV infection. So a synergistic action of these factors may lay the foundation for the development of some skin cancers.

Keywords: Papillomavirus, Human   Ultravioletrays   Skin neoplasms  
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[1] Pfister H.Chapter 8:Human papillomavirus and skin cancer.J Natl Cancer Inst Monogr,2003,(31):52-56.
[2] Aubin F,Humbey O,Guerrini JS,et al.Non-melanoma skin cancers and human papillomavirus.Ann Dermatol Venereol,2003,130:1131-1138.
[3] Forslund O,Lindelof B,Hradil E,et al.High prevalence of cutaneous human papillomavirus DNA on the top of skin tumors but not in "Stripped" biopsies from the same tumors.J Invest Dermatol,2004,123:388-394.
[4] Quereux G,N'Guyen JM,Dreno B.Human papillomavirus and extragenital in situ carcinoma.Dermatology,2004,209:40-45.
[5] Rohwedder A,Philips B,Malfetano J,et al.Vulvar malignant melanoma associated with human papillomavirus DNA:report of two cases and review of literature.Am J Dermatopathol,2002,24:230-240.
[6] Akgul B,Garcia-Escudero R,Ghali L,et al.The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin.Cancer Res,2005,65:2216-2223.
[7] Schaper ID,Marcuzzi GP,Weissenbom SJ,et al.Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8.Cancer Res,2005,65:1394-1400.
[8] Lisby S,Gniadecki R,Wulf HC.UV-induced DNA damage in human keratinocytes:quantitation and correlation with long-term survival.Exp Dermatol,2005,14:349-355.
[9] Ahn KS,Park KS,Jung KM,et al.Inhibitory effect of glycolic acid on ultraviolet B-induced c-fos expression,AP-1 activation and p53-p21 response in a human keratinocyte cell line.Cancer Lett,2002,186:125-135.
[10] Halliday GM.Inflammation,gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis.Mutat Res,2005,571:107-120.
[11] DeBuys HV,Levy SB,Murray JC,et al.Modern approaches to photoprotection.Dermatol Clin,2000,18:577-590.
[12] Woods GM,Malley RC,Muller HK.The skin immune system and the challenge of tumour immunosurveillance.Eur J Dermatol,2005,15:63-69.
[13] Runger TM,Vergilis I,Sarkar P,et al.How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer.Cell Cycle,2005,4:643-645.
[14] Termorshuizen F,Feltkamp MC,Struijk L,et al.Sunlight exposure and (sero)prevalence of epidermodysplasia verruciformis-associated human papillomavirus.J Invest Dermatol,2004,122:1456-1462.
[15] Akgul B,Lemme W,Garcia-Escudero R,et al.UV-B irradiation stimulates the promoter activity of the high-risk,cutaneous human papillomavirus 5 and 8 in primary keratinocytes.Arch Virol,2005,150:145-151.
[16] Wolf P,Seidl H,Back B,et al.Increased prevalence of human papillomavirus in hairs plucked from patients with psoriasis treated with psoralen-UV-A.Arch Dermatol,2004,140:317-324.
[17] Weissenborn SJ,Hopfl R,Weber F,et al.High prevalence of a variety of epidermodysplasia verruciformis-associated human papillomaviruses in psoriatic skin of patients treated or not treated with PUVA.J Invest Dermatol,1999,113:122-126.
[18] Giampieri S,Storey A.Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18.Br J Cancer,2004,90:2203-2209.
[19] Jackson S,Storey A.E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage.Oncogene,2000,19:592-598.
[20] Giampieri S,Garcia-Escudero R,Green J,et al.Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation.Oncogene,2004,23:5864-5870.
[21] Mouret S,Sauvaigo S,Peinnequin A,et al.E6* oncoprotein expression of human papillomavirus type-16 determines different ultraviolet sensitivity related to glutathione and glutathione peroxidase antioxidant defence.Exp Dermatol,2005,14:401-410.
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1���,����Ⱥ.������ͷ�������������߼�Ƥ������[J]. ����Ƥ���Բ�ѧ��־, 2006,32(1): 20-
2��÷�᷼,�ֱ���.֬���Խǻ������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2006,32(3): 174-
3�������,������,������.����ʪ���������״[J]. ����Ƥ���Բ�ѧ��־, 2008,34(3): 202-204
4������, ���긻.������ͷ��������Ⱦ���������ݻ���[J]. ����Ƥ���Բ�ѧ��־, 2003,29(1): 48-50
5��������, �ィ��, ������.HLA��̬�Ժ͹���HPV��Ⱦ��������������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2003,29(1): 54-57
6����Сǿ, Ϳ��ͥ.Rb������HPV�������[J]. ����Ƥ���Բ�ѧ��־, 2003,29(4): 256-258
7��������, ֣ï��, Ф����.HPV������ֲ����Ƥ�������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2004,30(2): 120-122
8�����޼�, ���Ӣ.�ڷ���HPV��Ⱦ����ͻ״ϸ����Ӧ���о�[J]. ����Ƥ���Բ�ѧ��־, 2004,30(3): 197-199
9���ξ�, ������, ��С��.����������ͷ�������ĸ�Ⱦ״����ĸӤ�������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2004,30(4): 265-267
10��������, ������, �ィ��.�ۺ�ø����Ӧ�������ͷ�������Ľ�չ[J]. ����Ƥ���Բ�ѧ��־, 2004,30(5): 326-328
11������, ����.��������ͷ��������Ⱦ�����в�ѧ�о���չ[J]. ����Ƥ���Բ�ѧ��־, 2005,31(1): 61-63
12������, �浤.�ʸ�˹ϸ����������ͷ��������Ⱦ[J]. ����Ƥ���Բ�ѧ��־, 2005,31(2): 113-115
13��÷�᷼, �ֱ���.֬���Խǻ������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2006,32(3): 174-176
14��������, ֣����.����������о���չ[J]. ����Ƥ���Բ�ѧ��־, 2006,32(5): 291-293
15��������, ��ǧ��.��������ѧ��HPV�о��еĽ�չ[J]. ����Ƥ���Բ�ѧ��־, 2007,33(1): 59-61

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